Ahring PK - Search Results

1

Discovery of a novel allosteric modulator of 5-HT3 receptors: inhibition and potentiation of Cys-loop receptor signaling through a conserved transmembrane intersubunit site.

Trattnig SM, Harpsøe K, Thygesen SB, Rahr LM, Ahring PK, Balle T, Jensen AA. Trattnig SM, et al. Among authors: ahring pk. J Biol Chem. 2012 Jul 20;287(30):25241-54. doi: 10.1074/jbc.M112.360370. Epub 2012 May 15. J Biol Chem. 2012. PMID: 22589534 Free PMC article.

2

Follow the allosteric transitions to predict variant pathogenicity: a channel-specific approach.

Absalom NL, El-Kamand S, Chua HC, Ahring PK. Absalom NL, et al. Among authors: ahring pk. Brain. 2024 May 3;147(5):e37-e40. doi: 10.1093/brain/awae008. Brain. 2024. PMID: 38198781 Free PMC article. No abstract available.

3

Correlations of receptor desensitization of gain-of-function GABRB3 variants with clinical severity.

Lin SXN, Ahring PK, Keramidas A, Liao VWY, Møller RS, Chebib M, Absalom NL. Lin SXN, et al. Among authors: ahring pk. Brain. 2024 Jan 4;147(1):224-239. doi: 10.1093/brain/awad285. Brain. 2024. PMID: 37647766 Free PMC article.

4

The beta subunit determines the ion selectivity of the GABAA receptor.

Jensen ML, Timmermann DB, Johansen TH, Schousboe A, Varming T, Ahring PK. Jensen ML, et al. Among authors: ahring pk. J Biol Chem. 2002 Nov 1;277(44):41438-47. doi: 10.1074/jbc.M205645200. Epub 2002 Aug 12. J Biol Chem. 2002. PMID: 12177063 Free article.

5

New ligands with affinity for the alpha4beta2 subtype of nicotinic acetylcholine receptors. Synthesis, receptor binding, and 3D-QSAR modeling.

Audouze K, Nielsen EØ, Olsen GM, Ahring P, Jørgensen TD, Peters D, Liljefors T, Balle T. Audouze K, et al. J Med Chem. 2006 Jun 1;49(11):3159-71. doi: 10.1021/jm058058h. J Med Chem. 2006. PMID: 16722635

6

Partial agonism and antagonism of the ionotropic glutamate receptor iGLuR5: structures of the ligand-binding core in complex with domoic acid and 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid.

Hald H, Naur P, Pickering DS, Sprogøe D, Madsen U, Timmermann DB, Ahring PK, Liljefors T, Schousboe A, Egebjerg J, Gajhede M, Kastrup JS. Hald H, et al. Among authors: ahring pk. J Biol Chem. 2007 Aug 31;282(35):25726-36. doi: 10.1074/jbc.M700137200. Epub 2007 Jun 20. J Biol Chem. 2007. PMID: 17581823 Free article.

7

Complementary three-dimensional quantitative structure-activity relationship modeling of binding affinity and functional potency: a study on alpha4beta2 nicotinic ligands.

Tosco P, Ahring PK, Dyhring T, Peters D, Harpsøe K, Liljefors T, Balle T. Tosco P, et al. Among authors: ahring pk. J Med Chem. 2009 Apr 23;52(8):2311-6. doi: 10.1021/jm801060h. J Med Chem. 2009. PMID: 19301898

8

Unraveling the high- and low-sensitivity agonist responses of nicotinic acetylcholine receptors.

Harpsøe K, Ahring PK, Christensen JK, Jensen ML, Peters D, Balle T. Harpsøe K, et al. Among authors: ahring pk. J Neurosci. 2011 Jul 27;31(30):10759-66. doi: 10.1523/JNEUROSCI.1509-11.2011. J Neurosci. 2011. PMID: 21795528 Free PMC article.

9

Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine α4β2 receptors: unique role of halogen bonding revealed.

Rohde LA, Ahring PK, Jensen ML, Nielsen EØ, Peters D, Helgstrand C, Krintel C, Harpsøe K, Gajhede M, Kastrup JS, Balle T. Rohde LA, et al. Among authors: ahring pk. J Biol Chem. 2012 Feb 3;287(6):4248-59. doi: 10.1074/jbc.M111.292243. Epub 2011 Dec 13. J Biol Chem. 2012. PMID: 22170047 Free PMC article.

10

Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors.

Harpsøe K, Hald H, Timmermann DB, Jensen ML, Dyhring T, Nielsen EØ, Peters D, Balle T, Gajhede M, Kastrup JS, Ahring PK. Harpsøe K, et al. Among authors: ahring pk. J Biol Chem. 2013 Jan 25;288(4):2559-70. doi: 10.1074/jbc.M112.436337. Epub 2012 Dec 10. J Biol Chem. 2013. PMID: 23229547 Free PMC article.

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