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Plasticity and cross-talk of interleukin 6-type cytokines.
Garbers C, Hermanns HM, Schaper F, Müller-Newen G, Grötzinger J, Rose-John S, Scheller J. Garbers C, et al. Among authors: grotzinger j. Cytokine Growth Factor Rev. 2012 Jun;23(3):85-97. doi: 10.1016/j.cytogfr.2012.04.001. Epub 2012 May 15. Cytokine Growth Factor Rev. 2012. PMID: 22595692 Review.
Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor.
Garbers C, Thaiss W, Jones GW, Waetzig GH, Lorenzen I, Guilhot F, Lissilaa R, Ferlin WG, Grötzinger J, Jones SA, Rose-John S, Scheller J. Garbers C, et al. Among authors: grotzinger j. J Biol Chem. 2011 Dec 16;286(50):42959-70. doi: 10.1074/jbc.M111.295758. Epub 2011 Oct 11. J Biol Chem. 2011. PMID: 21990364 Free PMC article.
An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer.
Garbers C, Spudy B, Aparicio-Siegmund S, Waetzig GH, Sommer J, Hölscher C, Rose-John S, Grötzinger J, Lorenzen I, Scheller J. Garbers C, et al. Among authors: grotzinger j. J Biol Chem. 2013 Feb 8;288(6):4346-54. doi: 10.1074/jbc.M112.432955. Epub 2012 Dec 3. J Biol Chem. 2013. PMID: 23209286 Free PMC article.
The amino acid exchange R28E in ciliary neurotrophic factor (CNTF) abrogates interleukin-6 receptor-dependent but retains CNTF receptor-dependent signaling via glycoprotein 130 (gp130)/leukemia inhibitory factor receptor (LIFR).
Wagener EM, Aurich M, Aparicio-Siegmund S, Floss DM, Garbers C, Breusing K, Rabe B, Schwanbeck R, Grötzinger J, Rose-John S, Scheller J. Wagener EM, et al. Among authors: grotzinger j. J Biol Chem. 2014 Jun 27;289(26):18442-50. doi: 10.1074/jbc.M114.568857. Epub 2014 May 6. J Biol Chem. 2014. PMID: 24802752 Free PMC article.
Proteolytic Cleavage Governs Interleukin-11 Trans-signaling.
Lokau J, Nitz R, Agthe M, Monhasery N, Aparicio-Siegmund S, Schumacher N, Wolf J, Möller-Hackbarth K, Waetzig GH, Grötzinger J, Müller-Newen G, Rose-John S, Scheller J, Garbers C. Lokau J, et al. Among authors: grotzinger j. Cell Rep. 2016 Feb 23;14(7):1761-1773. doi: 10.1016/j.celrep.2016.01.053. Epub 2016 Feb 11. Cell Rep. 2016. PMID: 26876177 Free article.
320 results