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Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95.
Park MA, Zhang G, Mitchell C, Rahmani M, Hamed H, Hagan MP, Yacoub A, Curiel DT, Fisher PB, Grant S, Dent P. Park MA, et al. Among authors: dent p. Mol Cancer Ther. 2008 Sep;7(9):2633-48. doi: 10.1158/1535-7163.MCT-08-0400. Mol Cancer Ther. 2008. PMID: 18790746 Free PMC article.
BCL-2 family inhibitors enhance histone deacetylase inhibitor and sorafenib lethality via autophagy and overcome blockade of the extrinsic pathway to facilitate killing.
Martin AP, Park MA, Mitchell C, Walker T, Rahmani M, Thorburn A, Häussinger D, Reinehr R, Grant S, Dent P. Martin AP, et al. Among authors: dent p. Mol Pharmacol. 2009 Aug;76(2):327-41. doi: 10.1124/mol.109.056309. Epub 2009 May 29. Mol Pharmacol. 2009. PMID: 19483105 Free PMC article.
Cisplatin enhances protein kinase R-like endoplasmic reticulum kinase- and CD95-dependent melanoma differentiation-associated gene-7/interleukin-24-induced killing in ovarian carcinoma cells.
Yacoub A, Liu R, Park MA, Hamed HA, Dash R, Schramm DN, Sarkar D, Dimitriev IP, Bell JK, Grant S, Farrell NP, Curiel DT, Fisher PB, Dent P. Yacoub A, et al. Among authors: dent p. Mol Pharmacol. 2010 Feb;77(2):298-310. doi: 10.1124/mol.109.061820. Epub 2009 Nov 12. Mol Pharmacol. 2010. PMID: 19910452 Free PMC article.
A serotype 5/3 adenovirus expressing MDA-7/IL-24 infects renal carcinoma cells and promotes toxicity of agents that increase ROS and ceramide levels.
Park MA, Hamed HA, Mitchell C, Cruickshanks N, Dash R, Allegood J, Dmitriev IP, Tye G, Ogretmen B, Spiegel S, Yacoub A, Grant S, Curiel DT, Fisher PB, Dent P. Park MA, et al. Among authors: dent p. Mol Pharmacol. 2011 Mar;79(3):368-80. doi: 10.1124/mol.110.069484. Epub 2010 Nov 30. Mol Pharmacol. 2011. PMID: 21119025 Free PMC article.
627 results