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Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs.
Yoshihara H, Fukushima T, Hakuno F, Saeki Y, Tanaka K, Ito A, Yoshida M, Iemura S, Natsume T, Asano T, Chida K, Girnita L, Takahashi S. Yoshihara H, et al. Among authors: chida k. Biochem Biophys Res Commun. 2012 Jun 22;423(1):122-7. doi: 10.1016/j.bbrc.2012.05.093. Epub 2012 May 23. Biochem Biophys Res Commun. 2012. PMID: 22634009
Phosphatidylinositol 3-kinase (PI3K) activity bound to insulin-like growth factor-I (IGF-I) receptor, which is continuously sustained by IGF-I stimulation, is required for IGF-I-induced cell proliferation.
Fukushima T, Nakamura Y, Yamanaka D, Shibano T, Chida K, Minami S, Asano T, Hakuno F, Takahashi S. Fukushima T, et al. Among authors: chida k. J Biol Chem. 2012 Aug 24;287(35):29713-21. doi: 10.1074/jbc.M112.393074. Epub 2012 Jul 5. J Biol Chem. 2012. PMID: 22767591 Free PMC article.
Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth factor-I receptor tyrosine kinases.
Fukushima T, Arai T, Ariga-Nedachi M, Okajima H, Ooi Y, Iijima Y, Sone M, Cho Y, Ando Y, Kasahara K, Ozoe A, Yoshihara H, Chida K, Okada S, Kopchick JJ, Asano T, Hakuno F, Takahashi S. Fukushima T, et al. Among authors: chida k. Biochem Biophys Res Commun. 2011 Jan 21;404(3):767-73. doi: 10.1016/j.bbrc.2010.12.045. Epub 2010 Dec 17. Biochem Biophys Res Commun. 2011. PMID: 21168390
869 results