Chan L - Search Results

1

A duplication CNV that conveys traits reciprocal to metabolic syndrome and protects against diet-induced obesity in mice and men.

Lacaria M, Saha P, Potocki L, Bi W, Yan J, Girirajan S, Burns B, Elsea S, Walz K, Chan L, Lupski JR, Gu W. Lacaria M, et al. Among authors: chan l. PLoS Genet. 2012;8(5):e1002713. doi: 10.1371/journal.pgen.1002713. Epub 2012 May 24. PLoS Genet. 2012. PMID: 22654670 Free PMC article.

2

Molecular mechanisms underlying fasting modulated liver insulin sensitivity and metabolism in male lipodystrophic Bscl2/Seipin-deficient mice.

Chen W, Zhou H, Saha P, Li L, Chan L. Chen W, et al. Among authors: chan l. Endocrinology. 2014 Nov;155(11):4215-25. doi: 10.1210/en.2014-1292. Epub 2014 Aug 5. Endocrinology. 2014. PMID: 25093462 Free PMC article.

3

Farnesoid X receptor is essential for normal glucose homeostasis.

Ma K, Saha PK, Chan L, Moore DD. Ma K, et al. Among authors: chan l. J Clin Invest. 2006 Apr;116(4):1102-9. doi: 10.1172/JCI25604. Epub 2006 Mar 23. J Clin Invest. 2006. PMID: 16557297 Free PMC article.

4

MeCP2 co-ordinates liver lipid metabolism with the NCoR1/HDAC3 corepressor complex.

Kyle SM, Saha PK, Brown HM, Chan LC, Justice MJ. Kyle SM, et al. Hum Mol Genet. 2016 Jul 15;25(14):3029-3041. doi: 10.1093/hmg/ddw156. Epub 2016 Jun 10. Hum Mol Genet. 2016. PMID: 27288453 Free PMC article.

5

Absence of adipose differentiation related protein upregulates hepatic VLDL secretion, relieves hepatosteatosis, and improves whole body insulin resistance in leptin-deficient mice.

Chang BH, Li L, Saha P, Chan L. Chang BH, et al. Among authors: chan l. J Lipid Res. 2010 Aug;51(8):2132-42. doi: 10.1194/jlr.M004515. Epub 2010 Apr 27. J Lipid Res. 2010. PMID: 20424269 Free PMC article.

6

The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic-acid methyl ester has potent anti-diabetic effects in diet-induced diabetic mice and Lepr(db/db) mice.

Saha PK, Reddy VT, Konopleva M, Andreeff M, Chan L. Saha PK, et al. Among authors: chan l. J Biol Chem. 2010 Dec 24;285(52):40581-92. doi: 10.1074/jbc.M110.176545. Epub 2010 Oct 18. J Biol Chem. 2010. PMID: 20956520 Free PMC article.

7

Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice.

Sun Y, Asnicar M, Saha PK, Chan L, Smith RG. Sun Y, et al. Among authors: chan l. Cell Metab. 2006 May;3(5):379-86. doi: 10.1016/j.cmet.2006.04.004. Cell Metab. 2006. PMID: 16679295 Free article.

8

Proinsulin-producing, hyperglycemia-induced adipose tissue macrophages underlie insulin resistance in high fat-fed diabetic mice.

Buras ED, Yang L, Saha P, Kim J, Mehta P, Yang Y, Hilsenbeck S, Kojima H, Chen W, Smith CW, Chan L. Buras ED, et al. Among authors: chan l. FASEB J. 2015 Aug;29(8):3537-48. doi: 10.1096/fj.15-271452. Epub 2015 May 7. FASEB J. 2015. PMID: 25953849 Free PMC article.

9

PLIN2 is a Key Regulator of the Unfolded Protein Response and Endoplasmic Reticulum Stress Resolution in Pancreatic β Cells.

Chen E, Tsai TH, Li L, Saha P, Chan L, Chang BH. Chen E, et al. Among authors: chan l. Sci Rep. 2017 Jan 19;7:40855. doi: 10.1038/srep40855. Sci Rep. 2017. PMID: 28102311 Free PMC article.

10

Deletion of hepatic carbohydrate response element binding protein (ChREBP) impairs glucose homeostasis and hepatic insulin sensitivity in mice.

Jois T, Chen W, Howard V, Harvey R, Youngs K, Thalmann C, Saha P, Chan L, Cowley MA, Sleeman MW. Jois T, et al. Among authors: chan l. Mol Metab. 2017 Nov;6(11):1381-1394. doi: 10.1016/j.molmet.2017.07.006. Epub 2017 Jul 18. Mol Metab. 2017. PMID: 29107286 Free PMC article.

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