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Dietary restriction attenuates age-associated muscle atrophy by lowering oxidative stress in mice even in complete absence of CuZnSOD.
Jang YC, Liu Y, Hayworth CR, Bhattacharya A, Lustgarten MS, Muller FL, Chaudhuri A, Qi W, Li Y, Huang JY, Verdin E, Richardson A, Van Remmen H. Jang YC, et al. Among authors: li y. Aging Cell. 2012 Oct;11(5):770-82. doi: 10.1111/j.1474-9726.2012.00843.x. Epub 2012 Aug 2. Aging Cell. 2012. PMID: 22672615 Free PMC article.
Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity.
Zhang Y, Ikeno Y, Qi W, Chaudhuri A, Li Y, Bokov A, Thorpe SR, Baynes JW, Epstein C, Richardson A, Van Remmen H. Zhang Y, et al. Among authors: li y. J Gerontol A Biol Sci Med Sci. 2009 Dec;64(12):1212-20. doi: 10.1093/gerona/glp132. Epub 2009 Sep 23. J Gerontol A Biol Sci Med Sci. 2009. PMID: 19776219 Free PMC article.
Rationale and Study Design of a Randomized Clinical Trial of Metformin to Prevent Frailty in Older Adults With Prediabetes.
Espinoza SE, Musi N, Wang CP, Michalek J, Orsak B, Romo T, Powers B, Conde A, Moris M, Bair-Kelps D, Li Y, Ganapathy V, Jergensen TE, Kelly LC, Jiwani R. Espinoza SE, et al. Among authors: li y. J Gerontol A Biol Sci Med Sci. 2020 Jan 1;75(1):102-109. doi: 10.1093/gerona/glz078. J Gerontol A Biol Sci Med Sci. 2020. PMID: 30888034 Free PMC article.
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