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Histones from dying renal cells aggravate kidney injury via TLR2 and TLR4.
Allam R, Scherbaum CR, Darisipudi MN, Mulay SR, Hägele H, Lichtnekert J, Hagemann JH, Rupanagudi KV, Ryu M, Schwarzenberger C, Hohenstein B, Hugo C, Uhl B, Reichel CA, Krombach F, Monestier M, Liapis H, Moreth K, Schaefer L, Anders HJ. Allam R, et al. Among authors: monestier m. J Am Soc Nephrol. 2012 Aug;23(8):1375-88. doi: 10.1681/ASN.2011111077. Epub 2012 Jun 7. J Am Soc Nephrol. 2012. PMID: 22677551 Free PMC article.
Extracellular histones are major mediators of death in sepsis.
Xu J, Zhang X, Pelayo R, Monestier M, Ammollo CT, Semeraro F, Taylor FB, Esmon NL, Lupu F, Esmon CT. Xu J, et al. Among authors: monestier m. Nat Med. 2009 Nov;15(11):1318-21. doi: 10.1038/nm.2053. Epub 2009 Oct 25. Nat Med. 2009. PMID: 19855397 Free PMC article.
127 results