Kochanek S - Search Results

1

Adenovirus vector-based in vitro neuronal cell model for Huntington's disease with human disease-like differential aggregation and degeneration.

Dong X, Zong S, Witting A, Lindenberg KS, Kochanek S, Huang B. Dong X, et al. Among authors: kochanek s. J Gene Med. 2012 Jul;14(7):468-81. doi: 10.1002/jgm.2641. J Gene Med. 2012. PMID: 22700462

2

High-capacity adenoviral vector-mediated reduction of huntingtin aggregate load in vitro and in vivo.

Huang B, Schiefer J, Sass C, Landwehrmeyer GB, Kosinski CM, Kochanek S. Huang B, et al. Among authors: kochanek s. Hum Gene Ther. 2007 Apr;18(4):303-11. doi: 10.1089/hum.2006.160. Hum Gene Ther. 2007. PMID: 17472569

3

Inducing huntingtin inclusion formation in primary neuronal cell culture and in vivo by high-capacity adenoviral vectors expressing truncated and full-length huntingtin with polyglutamine expansion.

Huang B, Schiefer J, Sass C, Kosinski CM, Kochanek S. Huang B, et al. Among authors: kochanek s. J Gene Med. 2008 Mar;10(3):269-79. doi: 10.1002/jgm.1150. J Gene Med. 2008. PMID: 18067195

4

ΔE1 and high-capacity adenoviral vectors expressing full-length codon-optimized merozoite surface protein 1 for vaccination against Plasmodium falciparum.

Zong S, Kron MW, Epp C, Engler T, Bujard H, Kochanek S, Kreppel F. Zong S, et al. Among authors: kochanek s. J Gene Med. 2011 Dec;13(12):670-9. doi: 10.1002/jgm.1627. J Gene Med. 2011. PMID: 22095915

5

HAP40 protein levels are huntingtin-dependent and decrease in Huntington disease.

Huang B, Seefelder M, Buck E, Engler T, Lindenberg KS, Klein F, Landwehrmeyer GB, Kochanek S. Huang B, et al. Among authors: kochanek s. Neurobiol Dis. 2021 Oct;158:105476. doi: 10.1016/j.nbd.2021.105476. Epub 2021 Aug 12. Neurobiol Dis. 2021. PMID: 34390835 Free article.

6

Adenovirus-mediated silencing of huntingtin expression by shRNA.

Huang B, Kochanek S. Huang B, et al. Among authors: kochanek s. Hum Gene Ther. 2005 May;16(5):618-26. doi: 10.1089/hum.2005.16.618. Hum Gene Ther. 2005. PMID: 15916486

7

Scalable production in human cells and biochemical characterization of full-length normal and mutant huntingtin.

Huang B, Lucas T, Kueppers C, Dong X, Krause M, Bepperling A, Buchner J, Voshol H, Weiss A, Gerrits B, Kochanek S. Huang B, et al. Among authors: kochanek s. PLoS One. 2015 Mar 23;10(3):e0121055. doi: 10.1371/journal.pone.0121055. eCollection 2015. PLoS One. 2015. PMID: 25799558 Free PMC article.

8

Pathological polyQ expansion does not alter the conformation of the Huntingtin-HAP40 complex.

Huang B, Guo Q, Niedermeier ML, Cheng J, Engler T, Maurer M, Pautsch A, Baumeister W, Stengel F, Kochanek S, Fernández-Busnadiego R. Huang B, et al. Among authors: kochanek s. Structure. 2021 Aug 5;29(8):804-809.e5. doi: 10.1016/j.str.2021.04.003. Epub 2021 Apr 27. Structure. 2021. PMID: 33909994 Free article.

9

The evolution of the huntingtin-associated protein 40 (HAP40) in conjunction with huntingtin.

Seefelder M, Alva V, Huang B, Engler T, Baumeister W, Guo Q, Fernández-Busnadiego R, Lupas AN, Kochanek S. Seefelder M, et al. Among authors: kochanek s. BMC Evol Biol. 2020 Dec 9;20(1):162. doi: 10.1186/s12862-020-01705-5. BMC Evol Biol. 2020. PMID: 33297953 Free PMC article.

10

Reductive amination as a strategy to reduce adenovirus vector promiscuity by chemical capsid modification with large polysaccharides.

Espenlaub S, Wortmann A, Engler T, Corjon S, Kochanek S, Kreppel F. Espenlaub S, et al. Among authors: kochanek s. J Gene Med. 2008 Dec;10(12):1303-14. doi: 10.1002/jgm.1262. J Gene Med. 2008. PMID: 18837065

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