Detty MR - Search Results

1

The ATPase activity of the P-glycoprotein drug pump is highly activated when the N-terminal and central regions of the nucleotide-binding domains are linked closely together.

Loo TW, Bartlett MC, Detty MR, Clarke DM. Loo TW, et al. Among authors: detty mr. J Biol Chem. 2012 Aug 3;287(32):26806-16. doi: 10.1074/jbc.M112.376202. Epub 2012 Jun 14. J Biol Chem. 2012. PMID: 22700974 Free PMC article.

2

Rhodamine inhibitors of P-glycoprotein: an amide/thioamide "switch" for ATPase activity.

Gannon MK 2nd, Holt JJ, Bennett SM, Wetzel BR, Loo TW, Bartlett MC, Clarke DM, Sawada GA, Higgins JW, Tombline G, Raub TJ, Detty MR. Gannon MK 2nd, et al. Among authors: detty mr. J Med Chem. 2009 May 28;52(10):3328-41. doi: 10.1021/jm900253g. J Med Chem. 2009. PMID: 19402665 Free PMC article.

3

Chalcogenopyrylium compounds as modulators of the ATP-binding cassette transporters P-glycoprotein (P-gp/ABCB1) and multidrug resistance protein 1 (MRP1/ABCC1).

Ebert SP, Wetzel B, Myette RL, Conseil G, Cole SP, Sawada GA, Loo TW, Bartlett MC, Clarke DM, Detty MR. Ebert SP, et al. Among authors: detty mr. J Med Chem. 2012 May 24;55(10):4683-99. doi: 10.1021/jm3004398. Epub 2012 May 10. J Med Chem. 2012. PMID: 22533905

4

Thiorhodamines containing amide and thioamide functionality as inhibitors of the ATP-binding cassette drug transporter P-glycoprotein (ABCB1).

Orchard A, Schamerhorn GA, Calitree BD, Sawada GA, Loo TW, Claire Bartlett M, Clarke DM, Detty MR. Orchard A, et al. Among authors: detty mr. Bioorg Med Chem. 2012 Jul 15;20(14):4290-302. doi: 10.1016/j.bmc.2012.05.075. Epub 2012 Jun 7. Bioorg Med Chem. 2012. PMID: 22727780 Free PMC article.

5

Stimulation of P-glycoprotein ATPase by analogues of tetramethylrosamine: coupling of drug binding at the "R" site to the ATP hydrolysis transition state.

Tombline G, Donnelly DJ, Holt JJ, You Y, Ye M, Gannon MK, Nygren CL, Detty MR. Tombline G, et al. Among authors: detty mr. Biochemistry. 2006 Jul 4;45(26):8034-47. doi: 10.1021/bi0603470. Biochemistry. 2006. PMID: 16800628

6

Chalcogenopyrylium dyes as differential modulators of organic anion transport by multidrug resistance protein 1 (MRP1), MRP2, and MRP4.

Myette RL, Conseil G, Ebert SP, Wetzel B, Detty MR, Cole SP. Myette RL, et al. Among authors: detty mr. Drug Metab Dispos. 2013 Jun;41(6):1231-9. doi: 10.1124/dmd.112.050831. Epub 2013 Mar 25. Drug Metab Dispos. 2013. PMID: 23530018 Free PMC article.

7

Analogues of tetramethylrosamine as transport molecules for and inhibitors of P-glycoprotein-mediated multidrug resistance.

Gibson SL, Hilf R, Donnelly DJ, Detty MR. Gibson SL, et al. Among authors: detty mr. Bioorg Med Chem. 2004 Sep 1;12(17):4625-31. doi: 10.1016/j.bmc.2004.06.034. Bioorg Med Chem. 2004. PMID: 15358289

8

Chalcogenopyrylium dyes as inhibitors/modulators of P-glycoprotein in multidrug-resistant cells.

Sawada GA, Raub TJ, William Higgins J, Brennan NK, Moore TM, Tombline G, Detty MR. Sawada GA, et al. Among authors: detty mr. Bioorg Med Chem. 2008 Nov 15;16(22):9745-56. doi: 10.1016/j.bmc.2008.09.065. Epub 2008 Sep 30. Bioorg Med Chem. 2008. PMID: 18849167

9

Selenorhodamine photosensitizers for photodynamic therapy of P-glycoprotein-expressing cancer cells.

Hill JE, Linder MK, Davies KS, Sawada GA, Morgan J, Ohulchanskyy TY, Detty MR. Hill JE, et al. Among authors: detty mr. J Med Chem. 2014 Oct 23;57(20):8622-34. doi: 10.1021/jm501259v. Epub 2014 Oct 1. J Med Chem. 2014. PMID: 25250825 Free PMC article.

10

ATP occlusion by P-glycoprotein as a surrogate measure for drug coupling.

Tombline G, Holt JJ, Gannon MK, Donnelly DJ, Wetzel B, Sawada GA, Raub TJ, Detty MR. Tombline G, et al. Among authors: detty mr. Biochemistry. 2008 Mar 11;47(10):3294-307. doi: 10.1021/bi7021393. Epub 2008 Feb 15. Biochemistry. 2008. PMID: 18275155

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