Shinomiya K - Search Results

1

Involvement of decreased hypoxia-inducible factor 1 activity and resultant G1-S cell cycle transition in radioresistance of perinecrotic tumor cells.

Zhu Y, Zhao T, Itasaka S, Zeng L, Yeom CJ, Hirota K, Suzuki K, Morinibu A, Shinomiya K, Ou G, Yoshimura M, Hiraoka M, Harada H. Zhu Y, et al. Among authors: shinomiya k. Oncogene. 2013 Apr 18;32(16):2058-68. doi: 10.1038/onc.2012.223. Epub 2012 Jun 18. Oncogene. 2013. PMID: 22710721 Free PMC article.

2

Aberrant IDH3α expression promotes malignant tumor growth by inducing HIF-1-mediated metabolic reprogramming and angiogenesis.

Zeng L, Morinibu A, Kobayashi M, Zhu Y, Wang X, Goto Y, Yeom CJ, Zhao T, Hirota K, Shinomiya K, Itasaka S, Yoshimura M, Guo G, Hammond EM, Hiraoka M, Harada H. Zeng L, et al. Among authors: shinomiya k. Oncogene. 2015 Sep 3;34(36):4758-66. doi: 10.1038/onc.2014.411. Epub 2014 Dec 22. Oncogene. 2015. PMID: 25531325

3

TS-1 enhances the effect of radiotherapy by suppressing radiation-induced hypoxia-inducible factor-1 activation and inducing endothelial cell apoptosis.

Zeng L, Ou G, Itasaka S, Harada H, Xie X, Shibuya K, Kizaka-Kondoh S, Morinibu A, Shinomiya K, Hiraoka M. Zeng L, et al. Among authors: shinomiya k. Cancer Sci. 2008 Nov;99(11):2327-35. doi: 10.1111/j.1349-7006.2008.00943.x. Epub 2008 Sep 22. Cancer Sci. 2008. PMID: 18823375 Free PMC article.

4

Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels.

Harada H, Inoue M, Itasaka S, Hirota K, Morinibu A, Shinomiya K, Zeng L, Ou G, Zhu Y, Yoshimura M, McKenna WG, Muschel RJ, Hiraoka M. Harada H, et al. Among authors: shinomiya k. Nat Commun. 2012 Apr 17;3:783. doi: 10.1038/ncomms1786. Nat Commun. 2012. PMID: 22510688 Free PMC article.

5

LY6E: a conductor of malignant tumor growth through modulation of the PTEN/PI3K/Akt/HIF-1 axis.

Yeom CJ, Zeng L, Goto Y, Morinibu A, Zhu Y, Shinomiya K, Kobayashi M, Itasaka S, Yoshimura M, Hur CG, Kakeya H, Hammond EM, Hiraoka M, Harada H. Yeom CJ, et al. Among authors: shinomiya k. Oncotarget. 2016 Oct 4;7(40):65837-65848. doi: 10.18632/oncotarget.11670. Oncotarget. 2016. PMID: 27589564 Free PMC article.

6

Treatment regimen determines whether an HIF-1 inhibitor enhances or inhibits the effect of radiation therapy.

Harada H, Itasaka S, Zhu Y, Zeng L, Xie X, Morinibu A, Shinomiya K, Hiraoka M. Harada H, et al. Among authors: shinomiya k. Br J Cancer. 2009 Mar 10;100(5):747-57. doi: 10.1038/sj.bjc.6604939. Epub 2009 Feb 17. Br J Cancer. 2009. PMID: 19223896 Free PMC article.

7

The combination of hypoxia-response enhancers and an oxygen-dependent proteolytic motif enables real-time imaging of absolute HIF-1 activity in tumor xenografts.

Harada H, Kizaka-Kondoh S, Itasaka S, Shibuya K, Morinibu A, Shinomiya K, Hiraoka M. Harada H, et al. Among authors: shinomiya k. Biochem Biophys Res Commun. 2007 Sep 7;360(4):791-6. doi: 10.1016/j.bbrc.2007.06.149. Epub 2007 Jul 5. Biochem Biophys Res Commun. 2007. PMID: 17624305

8

Diameter of tumor blood vessels is a good parameter to estimate HIF-1-active regions in solid tumors.

Harada H, Xie X, Itasaka S, Zeng L, Zhu Y, Morinibu A, Shinomiya K, Hiraoka M. Harada H, et al. Among authors: shinomiya k. Biochem Biophys Res Commun. 2008 Sep 5;373(4):533-8. doi: 10.1016/j.bbrc.2008.06.062. Epub 2008 Jun 27. Biochem Biophys Res Commun. 2008. PMID: 18586004

9

The Akt/mTOR pathway assures the synthesis of HIF-1alpha protein in a glucose- and reoxygenation-dependent manner in irradiated tumors.

Harada H, Itasaka S, Kizaka-Kondoh S, Shibuya K, Morinibu A, Shinomiya K, Hiraoka M. Harada H, et al. Among authors: shinomiya k. J Biol Chem. 2009 Feb 20;284(8):5332-42. doi: 10.1074/jbc.M806653200. Epub 2008 Dec 19. J Biol Chem. 2009. PMID: 19098000 Free article.

10

HIF-1-mediated metabolic reprogramming reduces ROS levels and facilitates the metastatic colonization of cancers in lungs.

Zhao T, Zhu Y, Morinibu A, Kobayashi M, Shinomiya K, Itasaka S, Yoshimura M, Guo G, Hiraoka M, Harada H. Zhao T, et al. Among authors: shinomiya k. Sci Rep. 2014 Jan 23;4:3793. doi: 10.1038/srep03793. Sci Rep. 2014. PMID: 24452734 Free PMC article.

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