Shaik S - Search Results

1

SCF(β-TRCP) suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2.

Shaik S, Nucera C, Inuzuka H, Gao D, Garnaas M, Frechette G, Harris L, Wan L, Fukushima H, Husain A, Nose V, Fadda G, Sadow PM, Goessling W, North T, Lawler J, Wei W. Shaik S, et al. J Exp Med. 2012 Jul 2;209(7):1289-307. doi: 10.1084/jem.20112446. Epub 2012 Jun 18. J Exp Med. 2012. PMID: 22711876 Free PMC article.

2

Novel insights into the molecular mechanisms governing Mdm2 ubiquitination and destruction.

Inuzuka H, Fukushima H, Shaik S, Wei W. Inuzuka H, et al. Among authors: shaik s. Oncotarget. 2010 Nov;1(7):685-690. doi: 10.18632/oncotarget.202. Oncotarget. 2010. PMID: 21317463 Free PMC article. Review.

3

Mcl-1 ubiquitination and destruction.

Inuzuka H, Fukushima H, Shaik S, Liu P, Lau AW, Wei W. Inuzuka H, et al. Among authors: shaik s. Oncotarget. 2011 Mar;2(3):239-44. doi: 10.18632/oncotarget.242. Oncotarget. 2011. PMID: 21608150 Free PMC article. Review.

4

mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR.

Gao D, Inuzuka H, Tan MK, Fukushima H, Locasale JW, Liu P, Wan L, Zhai B, Chin YR, Shaik S, Lyssiotis CA, Gygi SP, Toker A, Cantley LC, Asara JM, Harper JW, Wei W. Gao D, et al. Among authors: shaik s. Mol Cell. 2011 Oct 21;44(2):290-303. doi: 10.1016/j.molcel.2011.08.030. Mol Cell. 2011. PMID: 22017875 Free PMC article.

5

SCF(Fbw7) modulates the NFkB signaling pathway by targeting NFkB2 for ubiquitination and destruction.

Fukushima H, Matsumoto A, Inuzuka H, Zhai B, Lau AW, Wan L, Gao D, Shaik S, Yuan M, Gygi SP, Jimi E, Asara JM, Nakayama K, Nakayama KI, Wei W. Fukushima H, et al. Among authors: shaik s. Cell Rep. 2012 May 31;1(5):434-43. doi: 10.1016/j.celrep.2012.04.002. Cell Rep. 2012. PMID: 22708077 Free PMC article.

6

An evolving role for DEPTOR in tumor development and progression.

Wang Z, Zhong J, Inuzuka H, Gao D, Shaik S, Sarkar FH, Wei W. Wang Z, et al. Among authors: shaik s. Neoplasia. 2012 May;14(5):368-75. doi: 10.1593/neo.12542. Neoplasia. 2012. PMID: 22745583 Free PMC article. Review.

7

SCF β-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration.

Zhong J, Shaik S, Wan L, Tron AE, Wang Z, Sun L, Inuzuka H, Wei W. Zhong J, et al. Among authors: shaik s. Oncotarget. 2013 Dec;4(12):2339-53. doi: 10.18632/oncotarget.1446. Oncotarget. 2013. PMID: 24318128 Free PMC article.

8

Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase.

Inuzuka H, Tseng A, Gao D, Zhai B, Zhang Q, Shaik S, Wan L, Ang XL, Mock C, Yin H, Stommel JM, Gygi S, Lahav G, Asara J, Xiao ZX, Kaelin WG Jr, Harper JW, Wei W. Inuzuka H, et al. Among authors: shaik s. Cancer Cell. 2010 Aug 9;18(2):147-59. doi: 10.1016/j.ccr.2010.06.015. Cancer Cell. 2010. PMID: 20708156 Free PMC article.

9

Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.

Gao D, Wan L, Inuzuka H, Berg AH, Tseng A, Zhai B, Shaik S, Bennett E, Tron AE, Gasser JA, Lau A, Gygi SP, Harper JW, DeCaprio JA, Toker A, Wei W. Gao D, et al. Among authors: shaik s. Mol Cell. 2010 Sep 10;39(5):797-808. doi: 10.1016/j.molcel.2010.08.016. Mol Cell. 2010. PMID: 20832730 Free PMC article.

10

SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction.

Inuzuka H, Shaik S, Onoyama I, Gao D, Tseng A, Maser RS, Zhai B, Wan L, Gutierrez A, Lau AW, Xiao Y, Christie AL, Aster J, Settleman J, Gygi SP, Kung AL, Look T, Nakayama KI, DePinho RA, Wei W. Inuzuka H, et al. Among authors: shaik s. Nature. 2011 Mar 3;471(7336):104-9. doi: 10.1038/nature09732. Nature. 2011. PMID: 21368833 Free PMC article.

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