Sebti S - Search Results

1

Stat3 inhibition augments the immunogenicity of B-cell lymphoma cells, leading to effective antitumor immunity.

Cheng F, Wang H, Horna P, Wang Z, Shah B, Sahakian E, Woan KV, Villagra A, Pinilla-Ibarz J, Sebti S, Smith M, Tao J, Sotomayor EM. Cheng F, et al. Among authors: sebti s. Cancer Res. 2012 Sep 1;72(17):4440-8. doi: 10.1158/0008-5472.CAN-11-3619. Epub 2012 Jun 22. Cancer Res. 2012. PMID: 22728650 Free PMC article.

2

Combination therapy with AG-490 and interleukin 12 achieves greater antitumor effects than either agent alone.

Burdelya L, Catlett-Falcone R, Levitzki A, Cheng F, Mora LB, Sotomayor E, Coppola D, Sun J, Sebti S, Dalton WS, Jove R, Yu H. Burdelya L, et al. Among authors: sebti s. Mol Cancer Ther. 2002 Sep;1(11):893-9. Mol Cancer Ther. 2002. PMID: 12481410

3

Tipifarnib-mediated suppression of T-bet-dependent signaling pathways.

Bai F, Villagra AV, Zou J, Painter JS, Connolly K, Blaskovich MA, Sokol L, Sebti S, Djeu JY, Loughran TP, Wei S, Sotomayor E, Epling-Burnette P. Bai F, et al. Among authors: sebti s. Cancer Immunol Immunother. 2012 Apr;61(4):523-33. doi: 10.1007/s00262-011-1109-0. Epub 2011 Oct 9. Cancer Immunol Immunother. 2012. PMID: 21983879 Free PMC article.

4

Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt.

Yang L, Dan HC, Sun M, Liu Q, Sun XM, Feldman RI, Hamilton AD, Polokoff M, Nicosia SV, Herlyn M, Sebti SM, Cheng JQ. Yang L, et al. Cancer Res. 2004 Jul 1;64(13):4394-9. doi: 10.1158/0008-5472.CAN-04-0343. Cancer Res. 2004. PMID: 15231645

5

Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway.

Nefedova Y, Nagaraj S, Rosenbauer A, Muro-Cacho C, Sebti SM, Gabrilovich DI. Nefedova Y, et al. Among authors: sebti sm. Cancer Res. 2005 Oct 15;65(20):9525-35. doi: 10.1158/0008-5472.CAN-05-0529. Cancer Res. 2005. PMID: 16230418 Free PMC article.

6

A novel inhibitor of STAT3 homodimerization selectively suppresses STAT3 activity and malignant transformation.

Zhang X, Sun Y, Pireddu R, Yang H, Urlam MK, Lawrence HR, Guida WC, Lawrence NJ, Sebti SM. Zhang X, et al. Cancer Res. 2013 Mar 15;73(6):1922-33. doi: 10.1158/0008-5472.CAN-12-3175. Epub 2013 Jan 15. Cancer Res. 2013. PMID: 23322008 Free PMC article.

7

Targeting Aurora kinase A and JAK2 prevents GVHD while maintaining Treg and antitumor CTL function.

Betts BC, Veerapathran A, Pidala J, Yang H, Horna P, Walton K, Cubitt CL, Gunawan S, Lawrence HR, Lawrence NJ, Sebti SM, Anasetti C. Betts BC, et al. Among authors: sebti sm. Sci Transl Med. 2017 Jan 11;9(372):eaai8269. doi: 10.1126/scitranslmed.aai8269. Sci Transl Med. 2017. PMID: 28077684 Free PMC article.

8

Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice.

Blaskovich MA, Sun J, Cantor A, Turkson J, Jove R, Sebti SM. Blaskovich MA, et al. Cancer Res. 2003 Mar 15;63(6):1270-9. Cancer Res. 2003. PMID: 12649187

9

HG-829 is a potent noncompetitive inhibitor of the ATP-binding cassette multidrug resistance transporter ABCB1.

Caceres G, Robey RW, Sokol L, McGraw KL, Clark J, Lawrence NJ, Sebti SM, Wiese M, List AF. Caceres G, et al. Cancer Res. 2012 Aug 15;72(16):4204-13. doi: 10.1158/0008-5472.CAN-12-0743. Epub 2012 Jul 3. Cancer Res. 2012. PMID: 22761337 Free PMC article.

10

RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer.

Patel RA, Forinash KD, Pireddu R, Sun Y, Sun N, Martin MP, Schönbrunn E, Lawrence NJ, Sebti SM. Patel RA, et al. Cancer Res. 2012 Oct 1;72(19):5025-34. doi: 10.1158/0008-5472.CAN-12-0954. Epub 2012 Jul 30. Cancer Res. 2012. PMID: 22846914 Free PMC article.

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