Zimmer C - Search Results

1

Identification of small-molecule antagonists of the Pseudomonas aeruginosa transcriptional regulator PqsR: biophysically guided hit discovery and optimization.

Klein T, Henn C, de Jong JC, Zimmer C, Kirsch B, Maurer CK, Pistorius D, Müller R, Steinbach A, Hartmann RW. Klein T, et al. Among authors: zimmer c. ACS Chem Biol. 2012 Sep 21;7(9):1496-501. doi: 10.1021/cb300208g. Epub 2012 Jul 5. ACS Chem Biol. 2012. PMID: 22765028

2

Discovery of antagonists of PqsR, a key player in 2-alkyl-4-quinolone-dependent quorum sensing in Pseudomonas aeruginosa.

Lu C, Kirsch B, Zimmer C, de Jong JC, Henn C, Maurer CK, Müsken M, Häussler S, Steinbach A, Hartmann RW. Lu C, et al. Among authors: zimmer c. Chem Biol. 2012 Mar 23;19(3):381-90. doi: 10.1016/j.chembiol.2012.01.015. Chem Biol. 2012. PMID: 22444593

3

Validation of PqsD as an anti-biofilm target in Pseudomonas aeruginosa by development of small-molecule inhibitors.

Storz MP, Maurer CK, Zimmer C, Wagner N, Brengel C, de Jong JC, Lucas S, Müsken M, Häussler S, Steinbach A, Hartmann RW. Storz MP, et al. Among authors: zimmer c. J Am Chem Soc. 2012 Oct 3;134(39):16143-6. doi: 10.1021/ja3072397. Epub 2012 Sep 24. J Am Chem Soc. 2012. PMID: 22992202

4

Mechanistic details for anthraniloyl transfer in PqsD: the initial step in HHQ biosynthesis.

Hutter MC, Brengel C, Negri M, Henn C, Zimmer C, Hartmann RW, Empting M, Steinbach A. Hutter MC, et al. Among authors: zimmer c. J Mol Model. 2014 Jun;20(6):2255. doi: 10.1007/s00894-014-2255-z. Epub 2014 May 15. J Mol Model. 2014. PMID: 24842325

5

Optimization of the First Selective Steroid-11β-hydroxylase (CYP11B1) Inhibitors for the Treatment of Cortisol Dependent Diseases.

Hille UE, Zimmer C, Haupenthal J, Hartmann RW. Hille UE, et al. Among authors: zimmer c. ACS Med Chem Lett. 2011 Jun 3;2(8):559-64. doi: 10.1021/ml100283h. eCollection 2011 Aug 11. ACS Med Chem Lett. 2011. PMID: 24900349 Free PMC article.

6

First Selective CYP11B1 Inhibitors for the Treatment of Cortisol-Dependent Diseases.

Hille UE, Zimmer C, Vock CA, Hartmann RW. Hille UE, et al. Among authors: zimmer c. ACS Med Chem Lett. 2010 Oct 22;2(1):2-6. doi: 10.1021/ml100071j. eCollection 2011 Jan 13. ACS Med Chem Lett. 2010. PMID: 24900247 Free PMC article.

7

Heteroatom insertion into 3,4-dihydro-1H-quinolin-2-ones leads to potent and selective inhibitors of human and rat aldosterone synthase.

Grombein CM, Hu Q, Rau S, Zimmer C, Hartmann RW. Grombein CM, et al. Among authors: zimmer c. Eur J Med Chem. 2015 Jan 27;90:788-96. doi: 10.1016/j.ejmech.2014.12.022. Epub 2014 Dec 13. Eur J Med Chem. 2015. PMID: 25528333 Free article.

8

Fine-tuning the selectivity of aldosterone synthase inhibitors: structure-activity and structure-selectivity insights from studies of heteroaryl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-one derivatives.

Lucas S, Negri M, Heim R, Zimmer C, Hartmann RW. Lucas S, et al. Among authors: zimmer c. J Med Chem. 2011 Apr 14;54(7):2307-19. doi: 10.1021/jm101470k. Epub 2011 Mar 8. J Med Chem. 2011. PMID: 21384875

9

Exploiting the Chromone Scaffold for the Development of Inhibitors of Corticosteroid Biosynthesis.

Gobbi S, Hu Q, Zimmer C, Engel M, Belluti F, Rampa A, Hartmann RW, Bisi A. Gobbi S, et al. Among authors: zimmer c. J Med Chem. 2016 Mar 24;59(6):2468-77. doi: 10.1021/acs.jmedchem.5b01609. Epub 2016 Mar 11. J Med Chem. 2016. PMID: 26938274

10

N-(Pyridin-3-yl)benzamides as selective inhibitors of human aldosterone synthase (CYP11B2).

Zimmer C, Hafner M, Zender M, Ammann D, Hartmann RW, Vock CA. Zimmer C, et al. Bioorg Med Chem Lett. 2011 Jan 1;21(1):186-90. doi: 10.1016/j.bmcl.2010.11.040. Epub 2010 Nov 12. Bioorg Med Chem Lett. 2011. PMID: 21129965

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