Gelb MH - Search Results

1

Pharmacological characterization, structural studies, and in vivo activities of anti-Chagas disease lead compounds derived from tipifarnib.

Buckner FS, Bahia MT, Suryadevara PK, White KL, Shackleford DM, Chennamaneni NK, Hulverson MA, Laydbak JU, Chatelain E, Scandale I, Verlinde CL, Charman SA, Lepesheva GI, Gelb MH. Buckner FS, et al. Among authors: gelb mh. Antimicrob Agents Chemother. 2012 Sep;56(9):4914-21. doi: 10.1128/AAC.06244-11. Epub 2012 Jul 9. Antimicrob Agents Chemother. 2012. PMID: 22777048 Free PMC article.

2

The effects of protein farnesyltransferase inhibitors on trypanosomatids: inhibition of protein farnesylation and cell growth.

Yokoyama K, Trobridge P, Buckner FS, Scholten J, Stuart KD, Van Voorhis WC, Gelb MH. Yokoyama K, et al. Among authors: gelb mh. Mol Biochem Parasitol. 1998 Jul 1;94(1):87-97. doi: 10.1016/s0166-6851(98)00053-x. Mol Biochem Parasitol. 1998. PMID: 9719512

3

Protein farnesyltransferase from Trypanosoma brucei. A heterodimer of 61- and 65-kda subunits as a new target for antiparasite therapeutics.

Yokoyama K, Trobridge P, Buckner FS, Van Voorhis WC, Stuart KD, Gelb MH. Yokoyama K, et al. Among authors: gelb mh. J Biol Chem. 1998 Oct 9;273(41):26497-505. doi: 10.1074/jbc.273.41.26497. J Biol Chem. 1998. PMID: 9756885 Free article.

4

Selective tight binding inhibitors of trypanosomal glyceraldehyde-3-phosphate dehydrogenase via structure-based drug design.

Aronov AM, Verlinde CL, Hol WG, Gelb MH. Aronov AM, et al. Among authors: gelb mh. J Med Chem. 1998 Nov 19;41(24):4790-9. doi: 10.1021/jm9802620. J Med Chem. 1998. PMID: 9822549

5

Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase.

Aronov AM, Suresh S, Buckner FS, Van Voorhis WC, Verlinde CL, Opperdoes FR, Hol WG, Gelb MH. Aronov AM, et al. Among authors: gelb mh. Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4273-8. doi: 10.1073/pnas.96.8.4273. Proc Natl Acad Sci U S A. 1999. PMID: 10200252 Free PMC article.

6

Cloning, heterologous expression, and distinct substrate specificity of protein farnesyltransferase from Trypanosoma brucei.

Buckner FS, Yokoyama K, Nguyen L, Grewal A, Erdjument-Bromage H, Tempst P, Strickland CL, Xiao L, Van Voorhis WC, Gelb MH. Buckner FS, et al. Among authors: gelb mh. J Biol Chem. 2000 Jul 21;275(29):21870-6. doi: 10.1074/jbc.M000975200. J Biol Chem. 2000. PMID: 10749864 Free PMC article.

7

Adenosine analogues as inhibitors of Trypanosoma brucei phosphoglycerate kinase: elucidation of a novel binding mode for a 2-amino-N(6)-substituted adenosine.

Bressi JC, Choe J, Hough MT, Buckner FS, Van Voorhis WC, Verlinde CL, Hol WG, Gelb MH. Bressi JC, et al. Among authors: gelb mh. J Med Chem. 2000 Nov 2;43(22):4135-50. doi: 10.1021/jm000287a. J Med Chem. 2000. PMID: 11063610

8

Conformational changes in Leishmania mexicana glyceraldehyde-3-phosphate dehydrogenase induced by designed inhibitors.

Suresh S, Bressi JC, Kennedy KJ, Verlinde CL, Gelb MH, Hol WG. Suresh S, et al. Among authors: gelb mh. J Mol Biol. 2001 Jun 1;309(2):423-35. doi: 10.1006/jmbi.2001.4588. J Mol Biol. 2001. PMID: 11371162

9

Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design.

Bressi JC, Verlinde CL, Aronov AM, Shaw ML, Shin SS, Nguyen LN, Suresh S, Buckner FS, Van Voorhis WC, Kuntz ID, Hol WG, Gelb MH. Bressi JC, et al. Among authors: gelb mh. J Med Chem. 2001 Jun 21;44(13):2080-93. doi: 10.1021/jm000472o. J Med Chem. 2001. PMID: 11405646 Free PMC article.

10

Glycolysis as a target for the design of new anti-trypanosome drugs.

Verlinde CL, Hannaert V, Blonski C, Willson M, Périé JJ, Fothergill-Gilmore LA, Opperdoes FR, Gelb MH, Hol WG, Michels PA. Verlinde CL, et al. Among authors: gelb mh. Drug Resist Updat. 2001 Feb;4(1):50-65. doi: 10.1054/drup.2000.0177. Drug Resist Updat. 2001. PMID: 11512153 Review.

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