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Pharmacological characterization, structural studies, and in vivo activities of anti-Chagas disease lead compounds derived from tipifarnib.
Buckner FS, Bahia MT, Suryadevara PK, White KL, Shackleford DM, Chennamaneni NK, Hulverson MA, Laydbak JU, Chatelain E, Scandale I, Verlinde CL, Charman SA, Lepesheva GI, Gelb MH. Buckner FS, et al. Among authors: verlinde cl. Antimicrob Agents Chemother. 2012 Sep;56(9):4914-21. doi: 10.1128/AAC.06244-11. Epub 2012 Jul 9. Antimicrob Agents Chemother. 2012. PMID: 22777048 Free PMC article.
Efficacy, pharmacokinetics, and metabolism of tetrahydroquinoline inhibitors of Plasmodium falciparum protein farnesyltransferase.
Van Voorhis WC, Rivas KL, Bendale P, Nallan L, Hornéy C, Barrett LK, Bauer KD, Smart BP, Ankala S, Hucke O, Verlinde CL, Chakrabarti D, Strickland C, Yokoyama K, Buckner FS, Hamilton AD, Williams DK, Lombardo LJ, Floyd D, Gelb MH. Van Voorhis WC, et al. Among authors: verlinde cl. Antimicrob Agents Chemother. 2007 Oct;51(10):3659-71. doi: 10.1128/AAC.00246-07. Epub 2007 Jul 2. Antimicrob Agents Chemother. 2007. PMID: 17606674 Free PMC article.
Glycogen synthase kinase 3 is a potential drug target for African trypanosomiasis therapy.
Ojo KK, Gillespie JR, Riechers AJ, Napuli AJ, Verlinde CL, Buckner FS, Gelb MH, Domostoj MM, Wells SJ, Scheer A, Wells TN, Van Voorhis WC. Ojo KK, et al. Among authors: verlinde cl. Antimicrob Agents Chemother. 2008 Oct;52(10):3710-7. doi: 10.1128/AAC.00364-08. Epub 2008 Jul 21. Antimicrob Agents Chemother. 2008. PMID: 18644955 Free PMC article.
Second generation tetrahydroquinoline-based protein farnesyltransferase inhibitors as antimalarials.
Bendale P, Olepu S, Suryadevara PK, Bulbule V, Rivas K, Nallan L, Smart B, Yokoyama K, Ankala S, Pendyala PR, Floyd D, Lombardo LJ, Williams DK, Buckner FS, Chakrabarti D, Verlinde CL, Van Voorhis WC, Gelb MH. Bendale P, et al. Among authors: verlinde cl. J Med Chem. 2007 Sep 20;50(19):4585-605. doi: 10.1021/jm0703340. Epub 2007 Aug 28. J Med Chem. 2007. PMID: 17722901 Free PMC article.
120 results