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Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease.
Maalej E, Chabchoub F, Oset-Gasque MJ, Esquivias-Pérez M, González MP, Monjas L, Pérez C, de los Ríos C, Rodríguez-Franco MI, Iriepa I, Moraleda I, Chioua M, Romero A, Marco-Contelles J, Samadi A. Maalej E, et al. Among authors: chioua m. Eur J Med Chem. 2012 Aug;54:750-63. doi: 10.1016/j.ejmech.2012.06.038. Epub 2012 Jun 28. Eur J Med Chem. 2012. PMID: 22795665
Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer and neuronal vascular diseases. I. Synthesis, biological assessment, and molecular modeling of simple and readily available 2-aminopyridine-, and 2-chloropyridine-3,5-dicarbonitriles.
Samadi A, Marco-Contelles J, Soriano E, Alvarez-Pérez M, Chioua M, Romero A, González-Lafuente L, Gandía L, Roda JM, López MG, Villarroya M, García AG, Ríos Cde L. Samadi A, et al. Among authors: chioua m. Bioorg Med Chem. 2010 Aug 15;18(16):5861-72. doi: 10.1016/j.bmc.2010.06.095. Epub 2010 Jul 3. Bioorg Med Chem. 2010. PMID: 20656495
Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles.
Samadi A, Valderas C, de los Ríos C, Bastida A, Chioua M, González-Lafuente L, Colmena I, Gandía L, Romero A, Del Barrio L, Martín-de-Saavedra MD, López MG, Villarroya M, Marco-Contelles J. Samadi A, et al. Among authors: chioua m. Bioorg Med Chem. 2011 Jan 1;19(1):122-33. doi: 10.1016/j.bmc.2010.11.040. Epub 2010 Nov 26. Bioorg Med Chem. 2011. PMID: 21163662
Synthesis, structure, theoretical and experimental in vitro antioxidant/pharmacological properties of α-aryl, N-alkyl nitrones, as potential agents for the treatment of cerebral ischemia.
Samadi A, Soriano E, Revuelta J, Valderas C, Chioua M, Garrido I, Bartolomé B, Tomassolli I, Ismaili L, González-Lafuente L, Villarroya M, García AG, Oset-Gasque MJ, Marco-Contelles J. Samadi A, et al. Among authors: chioua m. Bioorg Med Chem. 2011 Jan 15;19(2):951-60. doi: 10.1016/j.bmc.2010.11.053. Epub 2010 Dec 7. Bioorg Med Chem. 2011. PMID: 21190861
Synthesis, analytical features, and biological relevance of 5-(3',4'-dihydroxyphenyl)-γ-valerolactone, a microbial metabolite derived from the catabolism of dietary flavan-3-ols.
Sanchez-Patan F, Chioua M, Garrido I, Cueva C, Samadi A, Marco-Contelles J, Moreno-Arribas MV, Bartolome B, Monagas M. Sanchez-Patan F, et al. Among authors: chioua m. J Agric Food Chem. 2011 Jul 13;59(13):7083-91. doi: 10.1021/jf2020182. Epub 2011 Jun 16. J Agric Food Chem. 2011. PMID: 21627328
Synthesis, biological assessment and molecular modeling of new multipotent MAO and cholinesterase inhibitors as potential drugs for the treatment of Alzheimer's disease.
Samadi A, Chioua M, Bolea I, de Los Ríos C, Iriepa I, Moraleda I, Bastida A, Esteban G, Unzeta M, Gálvez E, Marco-Contelles J. Samadi A, et al. Among authors: chioua m. Eur J Med Chem. 2011 Sep;46(9):4665-8. doi: 10.1016/j.ejmech.2011.05.048. Epub 2011 May 26. Eur J Med Chem. 2011. PMID: 21669479
Synthesis and pharmacological assessment of diversely substituted pyrazolo[3,4-b]quinoline, and benzo[b]pyrazolo[4,3-g][1,8]naphthyridine derivatives.
Silva D, Chioua M, Samadi A, Carmo Carreiras M, Jimeno ML, Mendes E, Ríos Cde L, Romero A, Villarroya M, López MG, Marco-Contelles J. Silva D, et al. Among authors: chioua m. Eur J Med Chem. 2011 Sep;46(9):4676-81. doi: 10.1016/j.ejmech.2011.05.068. Epub 2011 Jun 7. Eur J Med Chem. 2011. PMID: 21715067
58 results