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Brown fat ATP-citrate lyase links carbohydrate availability to thermogenesis and guards against metabolic stress.
Korobkina ED, Calejman CM, Haley JA, Kelly ME, Li H, Gaughan M, Chen Q, Pepper HL, Ahmad H, Boucher A, Fluharty SM, Lin TY, Lotun A, Peura J, Trefely S, Green CR, Vo P, Semenkovich CF, Pitarresi JR, Spinelli JB, Aydemir O, Metallo CM, Lynes MD, Jang C, Snyder NW, Wellen KE, Guertin DA. Korobkina ED, et al. Among authors: li h. Nat Metab. 2024 Nov;6(11):2187-2202. doi: 10.1038/s42255-024-01143-3. Epub 2024 Oct 14. Nat Metab. 2024. PMID: 39402290
Brown fat organogenesis and maintenance requires AKT1 and AKT2.
Sanchez-Gurmaches J, Martinez Calejman C, Jung SM, Li H, Guertin DA. Sanchez-Gurmaches J, et al. Among authors: li h. Mol Metab. 2019 May;23:60-74. doi: 10.1016/j.molmet.2019.02.004. Epub 2019 Feb 20. Mol Metab. 2019. PMID: 30833219 Free PMC article.
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