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Discovery of a Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase inhibitor (R,Z)-N-((1-ethylpyrrolidin-2-yl)methyl)-2-(2-fluorobenzylidene)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide (ML276) that reduces parasite growth in vitro.
Preuss J, Maloney P, Peddibhotla S, Hedrick MP, Hershberger P, Gosalia P, Milewski M, Li YL, Sugarman E, Hood B, Suyama E, Nguyen K, Vasile S, Sergienko E, Mangravita-Novo A, Vicchiarelli M, McAnally D, Smith LH, Roth GP, Diwan J, Chung TD, Jortzik E, Rahlfs S, Becker K, Pinkerton AB, Bode L. Preuss J, et al. Among authors: jortzik e. J Med Chem. 2012 Aug 23;55(16):7262-72. doi: 10.1021/jm300833h. Epub 2012 Aug 6. J Med Chem. 2012. PMID: 22813531 Free PMC article.
High-throughput screening for small-molecule inhibitors of plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase.
Preuss J, Hedrick M, Sergienko E, Pinkerton A, Mangravita-Novo A, Smith L, Marx C, Fischer E, Jortzik E, Rahlfs S, Becker K, Bode L. Preuss J, et al. Among authors: jortzik e. J Biomol Screen. 2012 Jul;17(6):738-51. doi: 10.1177/1087057112442382. Epub 2012 Apr 11. J Biomol Screen. 2012. PMID: 22496096 Free PMC article.
Glucose-6-phosphate metabolism in Plasmodium falciparum.
Preuss J, Jortzik E, Becker K. Preuss J, et al. Among authors: jortzik e. IUBMB Life. 2012 Jul;64(7):603-11. doi: 10.1002/iub.1047. Epub 2012 May 28. IUBMB Life. 2012. PMID: 22639416 Review.
H2O2 dynamics in the malaria parasite Plasmodium falciparum.
Rahbari M, Rahlfs S, Jortzik E, Bogeski I, Becker K. Rahbari M, et al. Among authors: jortzik e. PLoS One. 2017 Apr 3;12(4):e0174837. doi: 10.1371/journal.pone.0174837. eCollection 2017. PLoS One. 2017. PMID: 28369083 Free PMC article.
28 results