Brady RO - Search Results

1

An innovative approach to the treatment of Gaucher disease and possibly other metabolic disorders of the brain.

Brady RO, Yang C, Zhuang Z. Brady RO, et al. J Inherit Metab Dis. 2013 May;36(3):451-4. doi: 10.1007/s10545-012-9515-9. Epub 2012 Jul 20. J Inherit Metab Dis. 2013. PMID: 22814681 Free PMC article. Review.

2

Histone deacetylase inhibitors prevent the degradation and restore the activity of glucocerebrosidase in Gaucher disease.

Lu J, Yang C, Chen M, Ye DY, Lonser RR, Brady RO, Zhuang Z. Lu J, et al. Among authors: brady ro. Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21200-5. doi: 10.1073/pnas.1119181109. Epub 2011 Dec 12. Proc Natl Acad Sci U S A. 2011. PMID: 22160715 Free PMC article.

3

Histone deacetylase inhibitors increase glucocerebrosidase activity in Gaucher disease by modulation of molecular chaperones.

Yang C, Rahimpour S, Lu J, Pacak K, Ikejiri B, Brady RO, Zhuang Z. Yang C, et al. Among authors: brady ro. Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):966-71. doi: 10.1073/pnas.1221046110. Epub 2012 Dec 31. Proc Natl Acad Sci U S A. 2013. PMID: 23277556 Free PMC article.

4

Celastrol increases glucocerebrosidase activity in Gaucher disease by modulating molecular chaperones.

Yang C, Swallows CL, Zhang C, Lu J, Xiao H, Brady RO, Zhuang Z. Yang C, et al. Among authors: brady ro. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):249-54. doi: 10.1073/pnas.1321341111. Epub 2013 Dec 18. Proc Natl Acad Sci U S A. 2014. PMID: 24351928 Free PMC article.

5

Decreased glucocerebrosidase activity in Gaucher disease parallels quantitative enzyme loss due to abnormal interaction with TCP1 and c-Cbl.

Lu J, Chiang J, Iyer RR, Thompson E, Kaneski CR, Xu DS, Yang C, Chen M, Hodes RJ, Lonser RR, Brady RO, Zhuang Z. Lu J, et al. Among authors: brady ro. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21665-70. doi: 10.1073/pnas.1014376107. Epub 2010 Nov 22. Proc Natl Acad Sci U S A. 2010. PMID: 21098288 Free PMC article.

6

Histone deacetylase inhibitors are neuroprotective and preserve NGF-mediated cell survival following traumatic brain injury.

Lu J, Frerich JM, Turtzo LC, Li S, Chiang J, Yang C, Wang X, Zhang C, Wu C, Sun Z, Niu G, Zhuang Z, Brady RO, Chen X. Lu J, et al. Among authors: brady ro. Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10747-52. doi: 10.1073/pnas.1308950110. Epub 2013 Jun 10. Proc Natl Acad Sci U S A. 2013. PMID: 23754423 Free PMC article.

7

Mutant glucocerebrosidase in Gaucher disease recruits Hsp27 to the Hsp90 chaperone complex for proteasomal degradation.

Yang C, Wang H, Zhu D, Hong CS, Dmitriev P, Zhang C, Li Y, Ikejiri B, Brady RO, Zhuang Z. Yang C, et al. Among authors: brady ro. Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1137-42. doi: 10.1073/pnas.1424288112. Epub 2015 Jan 12. Proc Natl Acad Sci U S A. 2015. PMID: 25583479 Free PMC article.

8

Missense mutations in the NF2 gene result in the quantitative loss of merlin protein and minimally affect protein intrinsic function.

Yang C, Asthagiri AR, Iyer RR, Lu J, Xu DS, Ksendzovsky A, Brady RO, Zhuang Z, Lonser RR. Yang C, et al. Among authors: brady ro. Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4980-5. doi: 10.1073/pnas.1102198108. Epub 2011 Mar 7. Proc Natl Acad Sci U S A. 2011. PMID: 21383154 Free PMC article.

9

β-Catenin signaling initiates the activation of astrocytes and its dysregulation contributes to the pathogenesis of astrocytomas.

Yang C, Iyer RR, Yu AC, Yong RL, Park DM, Weil RJ, Ikejiri B, Brady RO, Lonser RR, Zhuang Z. Yang C, et al. Among authors: brady ro. Proc Natl Acad Sci U S A. 2012 May 1;109(18):6963-8. doi: 10.1073/pnas.1118754109. Epub 2012 Apr 13. Proc Natl Acad Sci U S A. 2012. PMID: 22505738 Free PMC article.

10

Correlation between enzyme activity and substrate storage in a cell culture model system for Gaucher disease.

Schueler UH, Kolter T, Kaneski CR, Zirzow GC, Sandhoff K, Brady RO. Schueler UH, et al. Among authors: brady ro. J Inherit Metab Dis. 2004;27(5):649-58. doi: 10.1023/b:boli.0000042959.44318.7c. J Inherit Metab Dis. 2004. PMID: 15669681

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