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Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation.
Brenneis C, Sisignano M, Coste O, Altenrath K, Fischer MJ, Angioni C, Fleming I, Brandes RP, Reeh PW, Woolf CJ, Geisslinger G, Scholich K. Brenneis C, et al. Among authors: sisignano m. Mol Pain. 2011 Oct 4;7:78. doi: 10.1186/1744-8069-7-78. Mol Pain. 2011. PMID: 21970373 Free PMC article.
5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals.
Sisignano M, Park CK, Angioni C, Zhang DD, von Hehn C, Cobos EJ, Ghasemlou N, Xu ZZ, Kumaran V, Lu R, Grant A, Fischer MJ, Schmidtko A, Reeh P, Ji RR, Woolf CJ, Geisslinger G, Scholich K, Brenneis C. Sisignano M, et al. J Neurosci. 2012 May 2;32(18):6364-72. doi: 10.1523/JNEUROSCI.5793-11.2012. J Neurosci. 2012. PMID: 22553041 Free PMC article.
Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain.
Sisignano M, Angioni C, Park CK, Meyer Dos Santos S, Jordan H, Kuzikov M, Liu D, Zinn S, Hohman SW, Schreiber Y, Zimmer B, Schmidt M, Lu R, Suo J, Zhang DD, Schäfer SM, Hofmann M, Yekkirala AS, de Bruin N, Parnham MJ, Woolf CJ, Ji RR, Scholich K, Geisslinger G. Sisignano M, et al. Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12544-12549. doi: 10.1073/pnas.1613246113. Epub 2016 Oct 17. Proc Natl Acad Sci U S A. 2016. PMID: 27791151 Free PMC article.
GPVI and Thromboxane Receptor on Platelets Promote Proinflammatory Macrophage Phenotypes during Cutaneous Inflammation.
Pierre S, Linke B, Suo J, Tarighi N, Del Turco D, Thomas D, Ferreiros N, Stegner D, Frölich S, Sisignano M, Meyer Dos Santos S, deBruin N, Nüsing RM, Deller T, Nieswandt B, Geisslinger G, Scholich K. Pierre S, et al. Among authors: sisignano m. J Invest Dermatol. 2017 Mar;137(3):686-695. doi: 10.1016/j.jid.2016.09.036. Epub 2016 Nov 3. J Invest Dermatol. 2017. PMID: 27818280 Free article.
The leukotriene B4 receptors BLT1 and BLT2 form an antagonistic sensitizing system in peripheral sensory neurons.
Zinn S, Sisignano M, Kern K, Pierre S, Tunaru S, Jordan H, Suo J, Treutlein EM, Angioni C, Ferreiros N, Leffler A, DeBruin N, Offermanns S, Geisslinger G, Scholich K. Zinn S, et al. Among authors: sisignano m. J Biol Chem. 2017 Apr 14;292(15):6123-6134. doi: 10.1074/jbc.M116.769125. Epub 2017 Feb 27. J Biol Chem. 2017. PMID: 28242764 Free PMC article.
47 results