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Heterocyclic fused pyridone carboxylic acid M(1) positive allosteric modulators.
Kuduk SD, Di Marco CN, Chang RK, Ray WJ, Ma L, Wittmann M, Seager MA, Koeplinger KA, Thompson CD, Hartman GD, Bilodeau MT. Kuduk SD, et al. Among authors: chang rk. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2533-7. doi: 10.1016/j.bmcl.2010.02.096. Epub 2010 Mar 3. Bioorg Med Chem Lett. 2010. PMID: 20303264
MK-7622: A First-in-Class M1 Positive Allosteric Modulator Development Candidate.
Beshore DC, N Di Marco C, Chang RK, Greshock TJ, Ma L, Wittmann M, Seager MA, Koeplinger KA, Thompson CD, Fuerst J, Hartman GD, Bilodeau MT, Ray WJ, Kuduk SD. Beshore DC, et al. Among authors: chang rk. ACS Med Chem Lett. 2018 Apr 30;9(7):652-656. doi: 10.1021/acsmedchemlett.8b00095. eCollection 2018 Jul 12. ACS Med Chem Lett. 2018. PMID: 30034595 Free PMC article.
5-Piperazinyl pyridine carboxamide bradykinin B1 antagonists.
Kuduk SD, Di Marco CN, Chang RK, Wood MR, Kim JJ, Schirripa KM, Murphy KL, Ransom RW, Tang C, Torrent M, Ha S, Prueksaritanont T, Pettibone DJ, Bock MG. Kuduk SD, et al. Among authors: chang rk. Bioorg Med Chem Lett. 2006 May 15;16(10):2791-5. doi: 10.1016/j.bmcl.2006.01.112. Epub 2006 Mar 10. Bioorg Med Chem Lett. 2006. PMID: 16529929
Development of orally bioavailable and CNS penetrant biphenylaminocyclopropane carboxamide bradykinin B1 receptor antagonists.
Kuduk SD, Di Marco CN, Chang RK, Wood MR, Schirripa KM, Kim JJ, Wai JM, DiPardo RM, Murphy KL, Ransom RW, Harrell CM, Reiss DR, Holahan MA, Cook J, Hess JF, Sain N, Urban MO, Tang C, Prueksaritanont T, Pettibone DJ, Bock MG. Kuduk SD, et al. Among authors: chang rk. J Med Chem. 2007 Jan 25;50(2):272-82. doi: 10.1021/jm061094b. J Med Chem. 2007. PMID: 17228869
220 results