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The physiological effects of deleting the mouse SLC30A8 gene encoding zinc transporter-8 are influenced by gender and genetic background.
Pound LD, Sarkar SA, Ustione A, Dadi PK, Shadoan MK, Lee CE, Walters JA, Shiota M, McGuinness OP, Jacobson DA, Piston DW, Hutton JC, Powell DR, O'Brien RM. Pound LD, et al. Among authors: powell dr. PLoS One. 2012;7(7):e40972. doi: 10.1371/journal.pone.0040972. Epub 2012 Jul 19. PLoS One. 2012. PMID: 22829903 Free PMC article.
Deletion of the gene encoding the ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein (UGRP)/glucose-6-phosphatase catalytic subunit-beta results in lowered plasma cholesterol and elevated glucagon.
Wang Y, Oeser JK, Yang C, Sarkar S, Hackl SI, Hasty AH, McGuinness OP, Paradee W, Hutton JC, Powell DR, O'Brien RM. Wang Y, et al. Among authors: powell dr. J Biol Chem. 2006 Dec 29;281(52):39982-9. doi: 10.1074/jbc.M605858200. Epub 2006 Oct 5. J Biol Chem. 2006. PMID: 17023421 Free article.
Potential positive and negative consequences of ZnT8 inhibition.
Syring KE, Bosma KJ, Goleva SB, Singh K, Oeser JK, Lopez CA, Skaar EP, McGuinness OP, Davis LK, Powell DR, O'Brien RM. Syring KE, et al. Among authors: powell dr. J Endocrinol. 2020 Aug;246(2):189-205. doi: 10.1530/JOE-20-0138. J Endocrinol. 2020. PMID: 32485672 Free PMC article.
Improved glycemic control in mice lacking Sglt1 and Sglt2.
Powell DR, DaCosta CM, Gay J, Ding ZM, Smith M, Greer J, Doree D, Jeter-Jones S, Mseeh F, Rodriguez LA, Harris A, Buhring L, Platt KA, Vogel P, Brommage R, Shadoan MK, Sands AT, Zambrowicz B. Powell DR, et al. Am J Physiol Endocrinol Metab. 2013 Jan 15;304(2):E117-30. doi: 10.1152/ajpendo.00439.2012. Epub 2012 Nov 13. Am J Physiol Endocrinol Metab. 2013. PMID: 23149623 Free article.
Mice Lacking Gpr75 are Hypophagic and Thin.
Powell DR, Doree DD, DaCosta CM, Platt KA, Brommage R, Buhring L, Revelli JP, Shadoan MK. Powell DR, et al. Diabetes Metab Syndr Obes. 2022 Jan 5;15:45-58. doi: 10.2147/DMSO.S342799. eCollection 2022. Diabetes Metab Syndr Obes. 2022. PMID: 35023939 Free PMC article.
427 results