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Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.
Prasad S, Yadav VR, Sung B, Reuter S, Kannappan R, Deorukhkar A, Diagaradjane P, Wei C, Baladandayuthapani V, Krishnan S, Guha S, Aggarwal BB. Prasad S, et al. Among authors: kannappan r. Clin Cancer Res. 2012 Sep 15;18(18):4942-53. doi: 10.1158/1078-0432.CCR-11-2805. Epub 2012 Jul 25. Clin Cancer Res. 2012. PMID: 22832932 Free PMC article.
NF-κB addiction and its role in cancer: 'one size does not fit all'.
Chaturvedi MM, Sung B, Yadav VR, Kannappan R, Aggarwal BB. Chaturvedi MM, et al. Among authors: kannappan r. Oncogene. 2011 Apr 7;30(14):1615-30. doi: 10.1038/onc.2010.566. Epub 2010 Dec 20. Oncogene. 2011. PMID: 21170083 Free PMC article. Review.
γ-Tocotrienol but not γ-tocopherol blocks STAT3 cell signaling pathway through induction of protein-tyrosine phosphatase SHP-1 and sensitizes tumor cells to chemotherapeutic agents.
Kannappan R, Yadav VR, Aggarwal BB. Kannappan R, et al. J Biol Chem. 2010 Oct 22;285(43):33520-33529. doi: 10.1074/jbc.M110.158378. Epub 2010 Aug 18. J Biol Chem. 2010. Retraction in: J Biol Chem. 2016 Aug 5;291(32):16922. doi: 10.1074/jbc.A110.158378 PMID: 20720018 Free PMC article. Retracted.
Embelin suppresses osteoclastogenesis induced by receptor activator of NF-κB ligand and tumor cells in vitro through inhibition of the NF-κB cell signaling pathway.
Reuter S, Prasad S, Phromnoi K, Kannappan R, Yadav VR, Aggarwal BB. Reuter S, et al. Among authors: kannappan r. Mol Cancer Res. 2010 Oct;8(10):1425-36. doi: 10.1158/1541-7786.MCR-10-0141. Epub 2010 Sep 8. Mol Cancer Res. 2010. Retraction in: Mol Cancer Res. 2018 Sep;16(9):1443. doi: 10.1158/1541-7786.MCR-18-0818 PMID: 20826545 Free PMC article. Retracted.
A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents.
Phromnoi K, Reuter S, Sung B, Prasad S, Kannappan R, Yadav VR, Chanmahasathien W, Limtrakul P, Aggarwal BB. Phromnoi K, et al. Among authors: kannappan r. Mol Pharmacol. 2011 Feb;79(2):279-89. doi: 10.1124/mol.110.067512. Epub 2010 Oct 7. Mol Pharmacol. 2011. Retraction in: Mol Pharmacol. 2016 Jul;90(1):64. doi: 10.1124/mol.115.067512retraction PMID: 20930110 Free PMC article. Retracted.
Thiocolchicoside exhibits anticancer effects through downregulation of NF-κB pathway and its regulated gene products linked to inflammation and cancer.
Reuter S, Prasad S, Phromnoi K, Ravindran J, Sung B, Yadav VR, Kannappan R, Chaturvedi MM, Aggarwal BB. Reuter S, et al. Among authors: kannappan r. Cancer Prev Res (Phila). 2010 Nov;3(11):1462-72. doi: 10.1158/1940-6207.CAPR-10-0037. Epub 2010 Oct 26. Cancer Prev Res (Phila). 2010. PMID: 20978115 Free PMC article.
Ursolic acid, a pentacyclin triterpene, potentiates TRAIL-induced apoptosis through p53-independent up-regulation of death receptors: evidence for the role of reactive oxygen species and JNK.
Prasad S, Yadav VR, Kannappan R, Aggarwal BB. Prasad S, et al. Among authors: kannappan r. J Biol Chem. 2011 Feb 18;286(7):5546-57. doi: 10.1074/jbc.M110.183699. Epub 2010 Dec 14. J Biol Chem. 2011. Retraction in: J Biol Chem. 2016 Aug 5;291(32):16924. doi: 10.1074/jbc.A110.183699 PMID: 21156789 Free PMC article. Retracted.
Chemosensitization of tumors by resveratrol.
Gupta SC, Kannappan R, Reuter S, Kim JH, Aggarwal BB. Gupta SC, et al. Among authors: kannappan r. Ann N Y Acad Sci. 2011 Jan;1215:150-60. doi: 10.1111/j.1749-6632.2010.05852.x. Ann N Y Acad Sci. 2011. PMID: 21261654 Free PMC article. Review.
64 results