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Magnetic resonance imaging with hyperpolarized [1,4-(13)C2]fumarate allows detection of early renal acute tubular necrosis.
Clatworthy MR, Kettunen MI, Hu DE, Mathews RJ, Witney TH, Kennedy BW, Bohndiek SE, Gallagher FA, Jarvis LB, Smith KG, Brindle KM. Clatworthy MR, et al. Among authors: witney th. Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13374-9. doi: 10.1073/pnas.1205539109. Epub 2012 Jul 26. Proc Natl Acad Sci U S A. 2012. PMID: 22837393 Free PMC article.
Production of hyperpolarized [1,4-13C2]malate from [1,4-13C2]fumarate is a marker of cell necrosis and treatment response in tumors.
Gallagher FA, Kettunen MI, Hu DE, Jensen PR, Zandt RI, Karlsson M, Gisselsson A, Nelson SK, Witney TH, Bohndiek SE, Hansson G, Peitersen T, Lerche MH, Brindle KM. Gallagher FA, et al. Among authors: witney th. Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):19801-6. doi: 10.1073/pnas.0911447106. Epub 2009 Nov 10. Proc Natl Acad Sci U S A. 2009. PMID: 19903889 Free PMC article.
Rapid Imaging of Tumor Cell Death In Vivo Using the C2A Domain of Synaptotagmin-I.
Neves AA, Xie B, Fawcett S, Alam IS, Witney TH, de Backer MM, Summers J, Hughes W, McGuire S, Soloviev D, Miller J, Howat WJ, Hu DE, Rodrigues TB, Lewis DY, Brindle KM. Neves AA, et al. Among authors: witney th. J Nucl Med. 2017 Jun;58(6):881-887. doi: 10.2967/jnumed.116.183004. Epub 2017 Feb 16. J Nucl Med. 2017. PMID: 28209913 Free article.
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