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Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival.
Ramos FJ, Chen SC, Garelick MG, Dai DF, Liao CY, Schreiber KH, MacKay VL, An EH, Strong R, Ladiges WC, Rabinovitch PS, Kaeberlein M, Kennedy BK. Ramos FJ, et al. Among authors: liao cy. Sci Transl Med. 2012 Jul 25;4(144):144ra103. doi: 10.1126/scitranslmed.3003802. Sci Transl Med. 2012. PMID: 22837538 Free PMC article.
Will the real aging Sirtuin please stand up?
Liao CY, Kennedy BK. Liao CY, et al. Cell Res. 2012 Aug;22(8):1215-7. doi: 10.1038/cr.2012.62. Epub 2012 Apr 17. Cell Res. 2012. PMID: 22508266 Free PMC article.
Mouse models and aging: longevity and progeria.
Liao CY, Kennedy BK. Liao CY, et al. Curr Top Dev Biol. 2014;109:249-85. doi: 10.1016/B978-0-12-397920-9.00003-2. Curr Top Dev Biol. 2014. PMID: 24947239 Review.
SIRT6, oxidative stress, and aging.
Liao CY, Kennedy BK. Liao CY, et al. Cell Res. 2016 Feb;26(2):143-4. doi: 10.1038/cr.2016.8. Epub 2016 Jan 19. Cell Res. 2016. PMID: 26780861 Free PMC article.
C. elegans S6K Mutants Require a Creatine-Kinase-like Effector for Lifespan Extension.
McQuary PR, Liao CY, Chang JT, Kumsta C, She X, Davis A, Chu CC, Gelino S, Gomez-Amaro RL, Petrascheck M, Brill LM, Ladiges WC, Kennedy BK, Hansen M. McQuary PR, et al. Among authors: liao cy. Cell Rep. 2016 Mar 8;14(9):2059-2067. doi: 10.1016/j.celrep.2016.02.012. Epub 2016 Feb 25. Cell Rep. 2016. PMID: 26923601 Free PMC article.
Rapamycin Reverses Metabolic Deficits in Lamin A/C-Deficient Mice.
Liao CY, Anderson SS, Chicoine NH, Mayfield JR, Academia EC, Wilson JA, Pongkietisak C, Thompson MA, Lagmay EP, Miller DM, Hsu YM, McCormick MA, O'Leary MN, Kennedy BK. Liao CY, et al. Cell Rep. 2016 Dec 6;17(10):2542-2552. doi: 10.1016/j.celrep.2016.10.040. Cell Rep. 2016. PMID: 27926859 Free PMC article.
A novel rapamycin analog is highly selective for mTORC1 in vivo.
Schreiber KH, Arriola Apelo SI, Yu D, Brinkman JA, Velarde MC, Syed FA, Liao CY, Baar EL, Carbajal KA, Sherman DS, Ortiz D, Brunauer R, Yang SE, Tzannis ST, Kennedy BK, Lamming DW. Schreiber KH, et al. Among authors: liao cy. Nat Commun. 2019 Jul 19;10(1):3194. doi: 10.1038/s41467-019-11174-0. Nat Commun. 2019. PMID: 31324799 Free PMC article.
Lamin A to Z in normal aging.
Primmer SR, Liao CY, Kummert OMP, Kennedy BK. Primmer SR, et al. Among authors: liao cy. Aging (Albany NY). 2022 Oct 17;14(20):8150-8166. doi: 10.18632/aging.204342. Epub 2022 Oct 17. Aging (Albany NY). 2022. PMID: 36260869 Free PMC article.
416 results