Strelevitz TJ - Search Results

1

Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design.

Di L, Keefer C, Scott DO, Strelevitz TJ, Chang G, Bi YA, Lai Y, Duckworth J, Fenner K, Troutman MD, Obach RS. Di L, et al. Among authors: strelevitz tj. Eur J Med Chem. 2012 Nov;57:441-8. doi: 10.1016/j.ejmech.2012.06.043. Epub 2012 Jul 16. Eur J Med Chem. 2012. PMID: 22840492

2

Flavin-containing monooxygenase activity in hepatocytes and microsomes: in vitro characterization and in vivo scaling of benzydamine clearance.

Fisher MB, Yoon K, Vaughn ML, Strelevitz TJ, Foti RS. Fisher MB, et al. Among authors: strelevitz tj. Drug Metab Dispos. 2002 Oct;30(10):1087-93. doi: 10.1124/dmd.30.10.1087. Drug Metab Dispos. 2002. PMID: 12228184

3

Altered AZT (3'-azido-3'-deoxythymidine) glucuronidation kinetics in liver microsomes as an explanation for underprediction of in vivo clearance: comparison to hepatocytes and effect of incubation environment.

Engtrakul JJ, Foti RS, Strelevitz TJ, Fisher MB. Engtrakul JJ, et al. Among authors: strelevitz tj. Drug Metab Dispos. 2005 Nov;33(11):1621-7. doi: 10.1124/dmd.105.005058. Epub 2005 Jul 27. Drug Metab Dispos. 2005. PMID: 16049128

4

Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections.

Magee TV, Ripp SL, Li B, Buzon RA, Chupak L, Dougherty TJ, Finegan SM, Girard D, Hagen AE, Falcone MJ, Farley KA, Granskog K, Hardink JR, Huband MD, Kamicker BJ, Kaneko T, Knickerbocker MJ, Liras JL, Marra A, Medina I, Nguyen TT, Noe MC, Obach RS, O'Donnell JP, Penzien JB, Reilly UD, Schafer JR, Shen Y, Stone GG, Strelevitz TJ, Sun J, Tait-Kamradt A, Vaz AD, Whipple DA, Widlicka DW, Wishka DG, Wolkowski JP, Flanagan ME. Magee TV, et al. Among authors: strelevitz tj. J Med Chem. 2009 Dec 10;52(23):7446-57. doi: 10.1021/jm900729s. J Med Chem. 2009. PMID: 19775168

5

Deuterium isotope effects on drug pharmacokinetics. I. System-dependent effects of specific deuteration with aldehyde oxidase cleared drugs.

Sharma R, Strelevitz TJ, Gao H, Clark AJ, Schildknegt K, Obach RS, Ripp SL, Spracklin DK, Tremaine LM, Vaz AD. Sharma R, et al. Among authors: strelevitz tj. Drug Metab Dispos. 2012 Mar;40(3):625-34. doi: 10.1124/dmd.111.042770. Epub 2011 Dec 21. Drug Metab Dispos. 2012. PMID: 22190693

6

Hydralazine as a selective probe inactivator of aldehyde oxidase in human hepatocytes: estimation of the contribution of aldehyde oxidase to metabolic clearance.

Strelevitz TJ, Orozco CC, Obach RS. Strelevitz TJ, et al. Drug Metab Dispos. 2012 Jul;40(7):1441-8. doi: 10.1124/dmd.112.045195. Epub 2012 Apr 20. Drug Metab Dispos. 2012. PMID: 22522748

7

Clearance Prediction of Targeted Covalent Inhibitors by In Vitro-In Vivo Extrapolation of Hepatic and Extrahepatic Clearance Mechanisms.

Leung L, Yang X, Strelevitz TJ, Montgomery J, Brown MF, Zientek MA, Banfield C, Gilbert AM, Thorarensen A, Dowty ME. Leung L, et al. Among authors: strelevitz tj. Drug Metab Dispos. 2017 Jan;45(1):1-7. doi: 10.1124/dmd.116.072983. Epub 2016 Oct 26. Drug Metab Dispos. 2017. PMID: 27784718

8

Production of active recombinant human aldehyde oxidase (AOX) in the baculovirus expression vector system (BEVS) and deployment in a pre-clinical fraction-of-control AOX compound exposure assay.

Cronin CN, Liu J, Grable N, Strelevitz TJ, Obach RS, Carlo A. Cronin CN, et al. Among authors: strelevitz tj. Protein Expr Purif. 2021 Jan;177:105749. doi: 10.1016/j.pep.2020.105749. Epub 2020 Sep 7. Protein Expr Purif. 2021. PMID: 32911062

9

Corrigendum to 'Production of active recombinant human aldehyde oxidase (AOX) in the baculovirus expression vector system (BEVS) and deployment in a pre-clinical fraction-of-control AOX compound exposure assay' [Protein Expr. Purif. 177 (2020) 105749].

Cronin CN, Liu J, Grable N, Strelevitz TJ, Obach RS, Carlo A. Cronin CN, et al. Among authors: strelevitz tj. Protein Expr Purif. 2021 Mar;179:105769. doi: 10.1016/j.pep.2020.105769. Epub 2020 Oct 27. Protein Expr Purif. 2021. PMID: 33127220 No abstract available.

10

Projections of Drug-Drug Interactions Caused by Time-Dependent Inhibitors of Cytochrome P450 1A2, 2B6, 2C8, 2C9, 2C19, and 2D6 Using In Vitro Data in Static and Dynamic Models.

Tseng E, Lin J, Strelevitz TJ, DaSilva E, Goosen TC, Obach RS. Tseng E, et al. Among authors: strelevitz tj. Drug Metab Dispos. 2024 Feb 26:DMD-AR-2024-001660. doi: 10.1124/dmd.124.001660. Online ahead of print. Drug Metab Dispos. 2024. PMID: 38408867 Free article.

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