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Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1.
Chiba S, Baghdadi M, Akiba H, Yoshiyama H, Kinoshita I, Dosaka-Akita H, Fujioka Y, Ohba Y, Gorman JV, Colgan JD, Hirashima M, Uede T, Takaoka A, Yagita H, Jinushi M. Chiba S, et al. Among authors: takaoka a. Nat Immunol. 2012 Sep;13(9):832-42. doi: 10.1038/ni.2376. Epub 2012 Jul 29. Nat Immunol. 2012. PMID: 22842346 Free PMC article.
IRF-7 is the master regulator of type-I interferon-dependent immune responses.
Honda K, Yanai H, Negishi H, Asagiri M, Sato M, Mizutani T, Shimada N, Ohba Y, Takaoka A, Yoshida N, Taniguchi T. Honda K, et al. Among authors: takaoka a. Nature. 2005 Apr 7;434(7034):772-7. doi: 10.1038/nature03464. Epub 2005 Mar 30. Nature. 2005. PMID: 15800576 Free article.
Negative regulation of Toll-like-receptor signaling by IRF-4.
Negishi H, Ohba Y, Yanai H, Takaoka A, Honma K, Yui K, Matsuyama T, Taniguchi T, Honda K. Negishi H, et al. Among authors: takaoka a. Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15989-94. doi: 10.1073/pnas.0508327102. Epub 2005 Oct 19. Proc Natl Acad Sci U S A. 2005. PMID: 16236719 Free PMC article.
DNA sensors in innate immune system.
Takaoka A, Shinohara S. Takaoka A, et al. Uirusu. 2008 Jun;58(1):37-46. doi: 10.2222/jsv.58.37. Uirusu. 2008. PMID: 19122387 Free article. Review.
ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses.
Hayakawa S, Shiratori S, Yamato H, Kameyama T, Kitatsuji C, Kashigi F, Goto S, Kameoka S, Fujikura D, Yamada T, Mizutani T, Kazumata M, Sato M, Tanaka J, Asaka M, Ohba Y, Miyazaki T, Imamura M, Takaoka A. Hayakawa S, et al. Among authors: takaoka a. Nat Immunol. 2011 Jan;12(1):37-44. doi: 10.1038/ni.1963. Epub 2010 Nov 21. Nat Immunol. 2011. PMID: 21102435 Free article.
255 results