Tokunaga Y - Search Results

1

Structural basis for the Golgi association by the pleckstrin homology domain of the ceramide trafficking protein (CERT).

Sugiki T, Takeuchi K, Yamaji T, Takano T, Tokunaga Y, Kumagai K, Hanada K, Takahashi H, Shimada I. Sugiki T, et al. Among authors: tokunaga y. J Biol Chem. 2012 Sep 28;287(40):33706-18. doi: 10.1074/jbc.M112.367730. Epub 2012 Aug 6. J Biol Chem. 2012. PMID: 22869376 Free PMC article.

2

An NMR method for the determination of protein binding interfaces using TEMPOL-induced chemical shift perturbations.

Moriya J, Sakakura M, Tokunaga Y, Prosser RS, Shimada I. Moriya J, et al. Among authors: tokunaga y. Biochim Biophys Acta. 2009 Oct;1790(10):1368-76. doi: 10.1016/j.bbagen.2009.06.001. Epub 2009 Jun 8. Biochim Biophys Acta. 2009. PMID: 19520148

3

Allosteric enhancement of MAP kinase p38α's activity and substrate selectivity by docking interactions.

Tokunaga Y, Takeuchi K, Takahashi H, Shimada I. Tokunaga Y, et al. Nat Struct Mol Biol. 2014 Aug;21(8):704-11. doi: 10.1038/nsmb.2861. Epub 2014 Jul 20. Nat Struct Mol Biol. 2014. PMID: 25038803

4

Dynamic multidrug recognition by multidrug transcriptional repressor LmrR.

Takeuchi K, Tokunaga Y, Imai M, Takahashi H, Shimada I. Takeuchi K, et al. Among authors: tokunaga y. Sci Rep. 2014 Nov 18;4:6922. doi: 10.1038/srep06922. Sci Rep. 2014. PMID: 25403615 Free PMC article.

5

Improvement of Ligand Affinity and Thermodynamic Properties by NMR-Based Evaluation of Local Dynamics and Surface Complementarity in the Receptor-Bound State.

Mizukoshi Y, Takeuchi K, Arutaki M, Tokunaga Y, Takizawa T, Hanzawa H, Shimada I. Mizukoshi Y, et al. Among authors: tokunaga y. Angew Chem Int Ed Engl. 2016 Nov 14;55(47):14606-14609. doi: 10.1002/anie.201607474. Epub 2016 Oct 20. Angew Chem Int Ed Engl. 2016. PMID: 27762089

6

Forbidden Coherence Transfer of ¹⁹F Nuclei to Quantitatively Measure the Dynamics of a CF₃-Containing Ligand in Receptor-Bound States.

Tokunaga Y, Takeuchi K, Shimada I. Tokunaga Y, et al. Molecules. 2017 Sep 7;22(9):1492. doi: 10.3390/molecules22091492. Molecules. 2017. PMID: 28880244 Free PMC article.

7

Spotlight on the Ballet of Proteins: The Structural Dynamic Properties of Proteins Illuminated by Solution NMR.

Tokunaga Y, Viennet T, Arthanari H, Takeuchi K. Tokunaga Y, et al. Int J Mol Sci. 2020 Mar 6;21(5):1829. doi: 10.3390/ijms21051829. Int J Mol Sci. 2020. PMID: 32155847 Free PMC article. Review.

8

Structural Fingerprints of an Intact Monoclonal Antibody Acquired under Formulated Storage Conditions via ¹⁵N Direct Detection Nuclear Magnetic Resonance.

Tokunaga Y, Takeuchi K, Okude J, Ori K, Torizawa T, Shimada I. Tokunaga Y, et al. J Med Chem. 2020 May 28;63(10):5360-5366. doi: 10.1021/acs.jmedchem.0c00231. Epub 2020 May 6. J Med Chem. 2020. PMID: 32374601

9

Targeting the cryptic sites: NMR-based strategy to improve protein druggability by controlling the conformational equilibrium.

Mizukoshi Y, Takeuchi K, Tokunaga Y, Matsuo H, Imai M, Fujisaki M, Kamoshida H, Takizawa T, Hanzawa H, Shimada I. Mizukoshi Y, et al. Among authors: tokunaga y. Sci Adv. 2020 Sep 30;6(40):eabd0480. doi: 10.1126/sciadv.abd0480. Print 2020 Sep. Sci Adv. 2020. PMID: 32998885 Free PMC article.

10

Role of NMR in High Ordered Structure Characterization of Monoclonal Antibodies.

Tokunaga Y, Takeuchi K. Tokunaga Y, et al. Int J Mol Sci. 2020 Dec 22;22(1):46. doi: 10.3390/ijms22010046. Int J Mol Sci. 2020. PMID: 33375207 Free PMC article. Review.

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