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Targeting mannose-binding lectin confers long-lasting protection with a surprisingly wide therapeutic window in cerebral ischemia.
Orsini F, Villa P, Parrella S, Zangari R, Zanier ER, Gesuete R, Stravalaci M, Fumagalli S, Ottria R, Reina JJ, Paladini A, Micotti E, Ribeiro-Viana R, Rojo J, Pavlov VI, Stahl GL, Bernardi A, Gobbi M, De Simoni MG. Orsini F, et al. Among authors: stahl gl. Circulation. 2012 Sep 18;126(12):1484-94. doi: 10.1161/CIRCULATIONAHA.112.103051. Epub 2012 Aug 9. Circulation. 2012. PMID: 22879370 Free PMC article.
Mannose-binding lectin and its associated proteases (MASPs) mediate coagulation and its deficiency is a risk factor in developing complications from infection, including disseminated intravascular coagulation.
Takahashi K, Chang WC, Takahashi M, Pavlov V, Ishida Y, La Bonte L, Shi L, Fujita T, Stahl GL, Van Cott EM. Takahashi K, et al. Among authors: stahl gl. Immunobiology. 2011 Jan-Feb;216(1-2):96-102. doi: 10.1016/j.imbio.2010.02.005. Epub 2010 Mar 4. Immunobiology. 2011. PMID: 20399528 Free PMC article.
184 results