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Mammalian target of rapamycin (mTOR) induces proliferation and de-differentiation responses to three coordinate pathophysiologic stimuli (mechanical strain, hypoxia, and extracellular matrix remodeling) in rat bladder smooth muscle.
Aitken KJ, Tolg C, Panchal T, Leslie B, Yu J, Elkelini M, Sabha N, Tse DJ, Lorenzo AJ, Hassouna M, Bägli DJ. Aitken KJ, et al. Among authors: bagli dj. Am J Pathol. 2010 Jan;176(1):304-19. doi: 10.2353/ajpath.2010.080834. Epub 2009 Dec 17. Am J Pathol. 2010. PMID: 20019183 Free PMC article.
Mechanotransduction of extracellular signal-regulated kinases 1 and 2 mitogen-activated protein kinase activity in smooth muscle is dependent on the extracellular matrix and regulated by matrix metalloproteinases.
Aitken KJ, Block G, Lorenzo A, Herz D, Sabha N, Dessouki O, Fung F, Szybowska M, Craig L, Bägli DJ. Aitken KJ, et al. Among authors: bagli dj. Am J Pathol. 2006 Aug;169(2):459-70. doi: 10.2353/ajpath.2006.050969. Am J Pathol. 2006. PMID: 16877348 Free PMC article.
DNA Methylation Reduces the Yes-Associated Protein 1/WW Domain Containing Transcription Regulator 1 Pathway and Prevents Pathologic Remodeling during Bladder Obstruction by Limiting Expression of BDNF.
Sidler M, Aitken KJ, Jiang JX, Sotiropoulos C, Aggarwal P, Anees A, Chong C, Siebenaller A, Thanabalasingam T, White JM, Choufani S, Weksberg R, Sangiorgi B, Wrana J, Delgado-Olguin P, Bägli DJ. Sidler M, et al. Among authors: bagli dj. Am J Pathol. 2018 Oct;188(10):2177-2194. doi: 10.1016/j.ajpath.2018.06.024. Epub 2018 Aug 17. Am J Pathol. 2018. PMID: 30121256 Free article.
259 results