El-Tayeb A - Search Results

1

The platelet P2Y(12) receptor under normal and pathological conditions. Assessment with the radiolabeled selective antagonist [(3)H]PSB-0413.

Ohlmann P, Lecchi A, El-Tayeb A, Müller CE, Cattaneo M, Gachet C. Ohlmann P, et al. Purinergic Signal. 2013 Mar;9(1):59-66. doi: 10.1007/s11302-012-9329-0. Epub 2012 Aug 15. Purinergic Signal. 2013. PMID: 22892887 Free PMC article.

2

Synthesis and preliminary evaluation of [3H]PSB-0413, a selective antagonist radioligand for platelet P2Y12 receptors.

El-Tayeb A, Griessmeier KJ, Müller CE. El-Tayeb A, et al. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5450-2. doi: 10.1016/j.bmcl.2005.08.104. Epub 2005 Oct 5. Bioorg Med Chem Lett. 2005. PMID: 16213725

3

Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4, and P2Y6 receptors.

El-Tayeb A, Qi A, Müller CE. El-Tayeb A, et al. J Med Chem. 2006 Nov 30;49(24):7076-87. doi: 10.1021/jm060848j. J Med Chem. 2006. PMID: 17125260

4

Synthesis of uracil nucleotide analogs with a modified, acyclic ribose moiety as P2Y(2) receptor antagonists.

Sauer R, El-Tayeb A, Kaulich M, Müller CE. Sauer R, et al. Bioorg Med Chem. 2009 Jul 15;17(14):5071-9. doi: 10.1016/j.bmc.2009.05.062. Epub 2009 May 30. Bioorg Med Chem. 2009. PMID: 19523835

5

Nucleoside-5'-monophosphates as prodrugs of adenosine A2A receptor agonists activated by ecto-5'-nucleotidase.

El-Tayeb A, Iqbal J, Behrenswerth A, Romio M, Schneider M, Zimmermann H, Schrader J, Müller CE. El-Tayeb A, et al. J Med Chem. 2009 Dec 10;52(23):7669-77. doi: 10.1021/jm900538v. J Med Chem. 2009. PMID: 19580286

6

Synthesis of a hydrolytically stable, fluorescent-labeled ATP analog as a tool for probing adenylyl cyclases.

Emmrich T, El-Tayeb A, Taha H, Seifert R, Müller CE, Link A. Emmrich T, et al. Bioorg Med Chem Lett. 2010 Jan 1;20(1):232-5. doi: 10.1016/j.bmcl.2009.10.125. Epub 2009 Oct 30. Bioorg Med Chem Lett. 2010. PMID: 19914832

7

2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists.

Scheiff AB, Yerande SG, El-Tayeb A, Li W, Inamdar GS, Vasu KK, Sudarsanam V, Müller CE. Scheiff AB, et al. Bioorg Med Chem. 2010 Mar 15;18(6):2195-2203. doi: 10.1016/j.bmc.2010.01.072. Epub 2010 Feb 4. Bioorg Med Chem. 2010. PMID: 20188574

8

Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors.

El-Tayeb A, Qi A, Nicholas RA, Müller CE. El-Tayeb A, et al. J Med Chem. 2011 Apr 28;54(8):2878-90. doi: 10.1021/jm1016297. Epub 2011 Mar 21. J Med Chem. 2011. PMID: 21417463

9

N-substituted phenoxazine and acridone derivatives: structure-activity relationships of potent P2X4 receptor antagonists.

Hernandez-Olmos V, Abdelrahman A, El-Tayeb A, Freudendahl D, Weinhausen S, Müller CE. Hernandez-Olmos V, et al. J Med Chem. 2012 Nov 26;55(22):9576-88. doi: 10.1021/jm300845v. Epub 2012 Nov 1. J Med Chem. 2012. PMID: 23075067

10

Crystal structure of the human ecto-5'-nucleotidase (CD73): insights into the regulation of purinergic signaling.

Knapp K, Zebisch M, Pippel J, El-Tayeb A, Müller CE, Sträter N. Knapp K, et al. Structure. 2012 Dec 5;20(12):2161-73. doi: 10.1016/j.str.2012.10.001. Epub 2012 Nov 8. Structure. 2012. PMID: 23142347 Free article.

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