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Page 1
Engineered luciferase reporter from a deep sea shrimp utilizing a novel imidazopyrazinone substrate.
Hall MP, Unch J, Binkowski BF, Valley MP, Butler BL, Wood MG, Otto P, Zimmerman K, Vidugiris G, Machleidt T, Robers MB, Benink HA, Eggers CT, Slater MR, Meisenheimer PL, Klaubert DH, Fan F, Encell LP, Wood KV. Hall MP, et al. Among authors: zimmerman k. ACS Chem Biol. 2012 Nov 16;7(11):1848-57. doi: 10.1021/cb3002478. Epub 2012 Aug 30. ACS Chem Biol. 2012. PMID: 22894855 Free PMC article.
Target engagement and drug residence time can be observed in living cells with BRET.
Robers MB, Dart ML, Woodroofe CC, Zimprich CA, Kirkland TA, Machleidt T, Kupcho KR, Levin S, Hartnett JR, Zimmerman K, Niles AL, Ohana RF, Daniels DL, Slater M, Wood MG, Cong M, Cheng YQ, Wood KV. Robers MB, et al. Among authors: zimmerman k. Nat Commun. 2015 Dec 3;6:10091. doi: 10.1038/ncomms10091. Nat Commun. 2015. PMID: 26631872 Free PMC article.
Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement.
Vasta JD, Corona CR, Wilkinson J, Zimprich CA, Hartnett JR, Ingold MR, Zimmerman K, Machleidt T, Kirkland TA, Huwiler KG, Ohana RF, Slater M, Otto P, Cong M, Wells CI, Berger BT, Hanke T, Glas C, Ding K, Drewry DH, Huber KVM, Willson TM, Knapp S, Müller S, Meisenheimer PL, Fan F, Wood KV, Robers MB. Vasta JD, et al. Among authors: zimmerman k. Cell Chem Biol. 2018 Feb 15;25(2):206-214.e11. doi: 10.1016/j.chembiol.2017.10.010. Epub 2017 Nov 22. Cell Chem Biol. 2018. PMID: 29174542 Free PMC article.
Homogeneous Assay for Target Engagement Utilizing Bioluminescent Thermal Shift.
Dart ML, Machleidt T, Jost E, Schwinn MK, Robers MB, Shi C, Kirkland TA, Killoran MP, Wilkinson JM, Hartnett JR, Zimmerman K, Wood KV. Dart ML, et al. Among authors: zimmerman k. ACS Med Chem Lett. 2018 Apr 16;9(6):546-551. doi: 10.1021/acsmedchemlett.8b00081. eCollection 2018 Jun 14. ACS Med Chem Lett. 2018. PMID: 29937980 Free PMC article.
Newborn screening for common genetic variants associated with permanent hearing loss: Implementation in Ontario and a review of the first 3 years.
Kernohan KD, Gallagher L, Pigeon M, Yeh E, Lacaria M, Axford MM, MacCormick J, Papaioannou V, Quercia N, Rupar C, Zimmerman K, Weber S, Cushing SL, Chakraborty P. Kernohan KD, et al. Among authors: zimmerman k. Genet Med. 2025 Jan 19:101364. doi: 10.1016/j.gim.2025.101364. Online ahead of print. Genet Med. 2025. PMID: 39846246
725 results