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Ras inhibition via direct Ras binding--is there a path forward?
Wang W, Fang G, Rudolph J. Wang W, et al. Among authors: fang g. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5766-76. doi: 10.1016/j.bmcl.2012.07.082. Epub 2012 Aug 2. Bioorg Med Chem Lett. 2012. PMID: 22902659 Free article.
Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity.
Maurer T, Garrenton LS, Oh A, Pitts K, Anderson DJ, Skelton NJ, Fauber BP, Pan B, Malek S, Stokoe D, Ludlam MJ, Bowman KK, Wu J, Giannetti AM, Starovasnik MA, Mellman I, Jackson PK, Rudolph J, Wang W, Fang G. Maurer T, et al. Among authors: fang g. Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5299-304. doi: 10.1073/pnas.1116510109. Epub 2012 Mar 19. Proc Natl Acad Sci U S A. 2012. PMID: 22431598 Free PMC article.
Targeting protein-protein interaction by small molecules.
Jin L, Wang W, Fang G. Jin L, et al. Among authors: fang g. Annu Rev Pharmacol Toxicol. 2014;54:435-56. doi: 10.1146/annurev-pharmtox-011613-140028. Epub 2013 Oct 21. Annu Rev Pharmacol Toxicol. 2014. PMID: 24160698 Review.
2,037 results