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Sorafenib-induced hypothyroidism is associated with increased type 3 deiodination.
Abdulrahman RM, Verloop H, Hoftijzer H, Verburg E, Hovens GC, Corssmit EP, Reiners C, Gelderblom H, Pereira AM, Kapiteijn E, Romijn JA, Visser TJ, Smit JW. Abdulrahman RM, et al. J Clin Endocrinol Metab. 2010 Aug;95(8):3758-62. doi: 10.1210/jc.2009-2507. Epub 2010 May 19. J Clin Endocrinol Metab. 2010. PMID: 20484486 Clinical Trial.