Di L - Search Results

1

Statistical methods for analysis of time-dependent inhibition of cytochrome p450 enzymes.

Yates P, Eng H, Di L, Obach RS. Yates P, et al. Among authors: di l. Drug Metab Dispos. 2012 Dec;40(12):2289-96. doi: 10.1124/dmd.112.047233. Epub 2012 Aug 31. Drug Metab Dispos. 2012. PMID: 22942318

2

Species independence in brain tissue binding using brain homogenates.

Di L, Umland JP, Chang G, Huang Y, Lin Z, Scott DO, Troutman MD, Liston TE. Di L, et al. Drug Metab Dispos. 2011 Jul;39(7):1270-7. doi: 10.1124/dmd.111.038778. Epub 2011 Apr 7. Drug Metab Dispos. 2011. PMID: 21474681

3

A novel relay method for determining low-clearance values.

Di L, Trapa P, Obach RS, Atkinson K, Bi YA, Wolford AC, Tan B, McDonald TS, Lai Y, Tremaine LM. Di L, et al. Drug Metab Dispos. 2012 Sep;40(9):1860-5. doi: 10.1124/dmd.112.046425. Epub 2012 May 29. Drug Metab Dispos. 2012. PMID: 22645091

4

Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design.

Di L, Keefer C, Scott DO, Strelevitz TJ, Chang G, Bi YA, Lai Y, Duckworth J, Fenner K, Troutman MD, Obach RS. Di L, et al. Eur J Med Chem. 2012 Nov;57:441-8. doi: 10.1016/j.ejmech.2012.06.043. Epub 2012 Jul 16. Eur J Med Chem. 2012. PMID: 22840492

5

In vitro-in vivo correlation for low-clearance compounds using hepatocyte relay method.

Di L, Atkinson K, Orozco CC, Funk C, Zhang H, McDonald TS, Tan B, Lin J, Chang C, Obach RS. Di L, et al. Drug Metab Dispos. 2013 Dec;41(12):2018-23. doi: 10.1124/dmd.113.053322. Epub 2013 Jul 15. Drug Metab Dispos. 2013. PMID: 23857891

6

Aldehyde oxidase 1 (AOX1) in human liver cytosols: quantitative characterization of AOX1 expression level and activity relationship.

Fu C, Di L, Han X, Soderstrom C, Snyder M, Troutman MD, Obach RS, Zhang H. Fu C, et al. Among authors: di l. Drug Metab Dispos. 2013 Oct;41(10):1797-804. doi: 10.1124/dmd.113.053082. Epub 2013 Jul 15. Drug Metab Dispos. 2013. PMID: 23857892

7

A perspective on the prediction of drug pharmacokinetics and disposition in drug research and development.

Di L, Feng B, Goosen TC, Lai Y, Steyn SJ, Varma MV, Obach RS. Di L, et al. Drug Metab Dispos. 2013 Dec;41(12):1975-93. doi: 10.1124/dmd.113.054031. Epub 2013 Sep 24. Drug Metab Dispos. 2013. PMID: 24065860

8

The role of drug metabolizing enzymes in clearance.

Di L. Di L. Expert Opin Drug Metab Toxicol. 2014 Mar;10(3):379-93. doi: 10.1517/17425255.2014.876006. Epub 2014 Jan 7. Expert Opin Drug Metab Toxicol. 2014. PMID: 24392841 Review.

9

Consideration of the unbound drug concentration in enzyme kinetics.

Waters NJ, Obach RS, Di L. Waters NJ, et al. Among authors: di l. Methods Mol Biol. 2014;1113:119-45. doi: 10.1007/978-1-62703-758-7_7. Methods Mol Biol. 2014. PMID: 24523111 Review.

10

Metabolites in safety testing assessment in early clinical development: a case study with a glucokinase activator.

Sharma R, Litchfield J, Atkinson K, Eng H, Amin NB, Denney WS, Pettersen JC, Goosen TC, Di L, Lee E, Pfefferkorn JA, Dalvie DK, Kalgutkar AS. Sharma R, et al. Among authors: di l. Drug Metab Dispos. 2014 Nov;42(11):1926-39. doi: 10.1124/dmd.114.060087. Epub 2014 Aug 20. Drug Metab Dispos. 2014. PMID: 25142735

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