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Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase.
Salo-Ahen OM, Tochowicz A, Pozzi C, Cardinale D, Ferrari S, Boum Y, Mangani S, Stroud RM, Saxena P, Myllykallio H, Costi MP, Ponterini G, Wade RC. Salo-Ahen OM, et al. Among authors: stroud rm. J Med Chem. 2015 Apr 23;58(8):3572-81. doi: 10.1021/acs.jmedchem.5b00137. Epub 2015 Apr 1. J Med Chem. 2015. PMID: 25798950 Free PMC article.
Structure-based studies on species-specific inhibition of thymidylate synthase.
Costi MP, Tondi D, Rinaldi M, Barlocco D, Pecorari P, Soragni F, Venturelli A, Stroud RM. Costi MP, et al. Among authors: stroud rm. Biochim Biophys Acta. 2002 Jul 18;1587(2-3):206-14. doi: 10.1016/s0925-4439(02)00083-2. Biochim Biophys Acta. 2002. PMID: 12084462 Free article. Review.
402 results