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Page 1
Methylation at global LINE-1 repeats in human blood are affected by gender but not by age or natural hormone cycles.
El-Maarri O, Walier M, Behne F, van Üüm J, Singer H, Diaz-Lacava A, Nüsgen N, Niemann B, Watzka M, Reinsberg J, van der Ven H, Wienker T, Stoffel-Wagner B, Schwaab R, Oldenburg J. El-Maarri O, et al. Among authors: nusgen n. PLoS One. 2011 Jan 19;6(1):e16252. doi: 10.1371/journal.pone.0016252. PLoS One. 2011. PMID: 21311577 Free PMC article.
Methylation of L1Hs promoters is lower on the inactive X, has a tendency of being higher on autosomes in smaller genomes and shows inter-individual variability at some loci.
Singer H, Walier M, Nüsgen N, Meesters C, Schreiner F, Woelfle J, Fimmers R, Wienker T, Kalscheuer VM, Becker T, Schwaab R, Oldenburg J, El-Maarri O. Singer H, et al. Among authors: nusgen n. Hum Mol Genet. 2012 Jan 1;21(1):219-35. doi: 10.1093/hmg/ddr456. Epub 2011 Oct 4. Hum Mol Genet. 2012. PMID: 21972244 Free PMC article.
Inter-locus as well as intra-locus heterogeneity in LINE-1 promoter methylation in common human cancers suggests selective demethylation pressure at specific CpGs.
Nüsgen N, Goering W, Dauksa A, Biswas A, Jamil MA, Dimitriou I, Sharma A, Singer H, Fimmers R, Fröhlich H, Oldenburg J, Gulbinas A, Schulz WA, El-Maarri O. Nüsgen N, et al. Clin Epigenetics. 2015 Mar 1;7(1):17. doi: 10.1186/s13148-015-0051-y. eCollection 2015. Clin Epigenetics. 2015. PMID: 25798207 Free PMC article.