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Page 1
Targeting Notch, a key pathway for ovarian cancer stem cells, sensitizes tumors to platinum therapy.
McAuliffe SM, Morgan SL, Wyant GA, Tran LT, Muto KW, Chen YS, Chin KT, Partridge JC, Poole BB, Cheng KH, Daggett J Jr, Cullen K, Kantoff E, Hasselbatt K, Berkowitz J, Muto MG, Berkowitz RS, Aster JC, Matulonis UA, Dinulescu DM. McAuliffe SM, et al. Among authors: muto kw. Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):E2939-48. doi: 10.1073/pnas.1206400109. Epub 2012 Sep 27. Proc Natl Acad Sci U S A. 2012. PMID: 23019585 Free PMC article.
Cholesterol-tethered platinum II-based supramolecular nanoparticle increases antitumor efficacy and reduces nephrotoxicity.
Sengupta P, Basu S, Soni S, Pandey A, Roy B, Oh MS, Chin KT, Paraskar AS, Sarangi S, Connor Y, Sabbisetti VS, Kopparam J, Kulkarni A, Muto K, Amarasiriwardena C, Jayawardene I, Lupoli N, Dinulescu DM, Bonventre JV, Mashelkar RA, Sengupta S. Sengupta P, et al. Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11294-9. doi: 10.1073/pnas.1203129109. Epub 2012 Jun 25. Proc Natl Acad Sci U S A. 2012. PMID: 22733767 Free PMC article.
Harnessing structure-activity relationship to engineer a cisplatin nanoparticle for enhanced antitumor efficacy.
Paraskar AS, Soni S, Chin KT, Chaudhuri P, Muto KW, Berkowitz J, Handlogten MW, Alves NJ, Bilgicer B, Dinulescu DM, Mashelkar RA, Sengupta S. Paraskar AS, et al. Among authors: muto kw. Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12435-40. doi: 10.1073/pnas.1007026107. Epub 2010 Jun 23. Proc Natl Acad Sci U S A. 2010. PMID: 20616005 Free PMC article.