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Scaffold-hopping with zwitterionic CCR3 antagonists: identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092.
Bahl A, Barton P, Bowers K, Caffrey MV, Denton R, Gilmour P, Hawley S, Linannen T, Luckhurst CA, Mochel T, Perry MW, Riley RJ, Roe E, Springthorpe B, Stein L, Webborn P. Bahl A, et al. Among authors: gilmour p. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6694-9. doi: 10.1016/j.bmcl.2012.08.103. Epub 2012 Sep 11. Bioorg Med Chem Lett. 2012. PMID: 23021991
Semisynthetic guanidino lipoglycopeptides with potent in vitro and in vivo antibacterial activity.
van Groesen E, Mons E, Kotsogianni I, Arts M, Tehrani KHME, Wade N, Lysenko V, Stel FM, Zwerus JT, De Benedetti S, Bakker A, Chakraborty P, van der Stelt M, Scheffers DJ, Gooskens J, Smits WK, Holden K, Gilmour PS, Willemse J, Hitchcock CA, van Hasselt JGC, Schneider T, Martin NI. van Groesen E, et al. Among authors: gilmour ps. Sci Transl Med. 2024 Aug 7;16(759):eabo4736. doi: 10.1126/scitranslmed.abo4736. Epub 2024 Aug 7. Sci Transl Med. 2024. PMID: 39110780
Therapeutic α-1-microglobulin ameliorates kidney ischemia-reperfusion injury.
Burmakin M, Gilmour PS, Gram M, Shushakova N, Sandoval RM, Molitoris BA, Larsson TE. Burmakin M, et al. Among authors: gilmour ps. Am J Physiol Renal Physiol. 2024 Jul 1;327(1):F103-F112. doi: 10.1152/ajprenal.00067.2024. Epub 2024 May 23. Am J Physiol Renal Physiol. 2024. PMID: 38779750
Prognostic imaging biomarkers for diabetic kidney disease (iBEAt): study protocol.
Gooding KM, Lienczewski C, Papale M, Koivuviita N, Maziarz M, Dutius Andersson AM, Sharma K, Pontrelli P, Garcia Hernandez A, Bailey J, Tobin K, Saunavaara V, Zetterqvist A, Shelley D, Teh I, Ball C, Puppala S, Ibberson M, Karihaloo A, Metsärinne K, Banks RE, Gilmour PS, Mansfield M, Gilchrist M, de Zeeuw D, Heerspink HJL, Nuutila P, Kretzler M, Welberry Smith M, Gesualdo L, Andress D, Grenier N, Shore AC, Gomez MF, Sourbron S; BEAt-DKD consortium. Gooding KM, et al. Among authors: gilmour ps. BMC Nephrol. 2020 Jun 29;21(1):242. doi: 10.1186/s12882-020-01901-x. BMC Nephrol. 2020. PMID: 32600374 Free PMC article.
Validation of Plasma Biomarker Candidates for the Prediction of eGFR Decline in Patients With Type 2 Diabetes.
Heinzel A, Kammer M, Mayer G, Reindl-Schwaighofer R, Hu K, Perco P, Eder S, Rosivall L, Mark PB, Ju W, Kretzler M, Gilmour P, Wilson JM, Duffin KL, Abdalla M, McCarthy MI, Heinze G, Heerspink HL, Wiecek A, Gomez MF, Oberbauer R; BEAt-DKD Consortium. Heinzel A, et al. Among authors: gilmour p. Diabetes Care. 2018 Sep;41(9):1947-1954. doi: 10.2337/dc18-0532. Epub 2018 Jul 6. Diabetes Care. 2018. PMID: 29980527 Free PMC article.
Human stem cell osteoblastogenesis mediated by novel glycogen synthase kinase 3 inhibitors induces bone formation and a unique bone turnover biomarker profile in rats.
Gilmour PS, O'Shea PJ, Fagura M, Pilling JE, Sanganee H, Wada H, Courtney PF, Kavanagh S, Hall PA, Escott KJ. Gilmour PS, et al. Toxicol Appl Pharmacol. 2013 Oct 15;272(2):399-407. doi: 10.1016/j.taap.2013.07.001. Epub 2013 Jul 18. Toxicol Appl Pharmacol. 2013. PMID: 23872097 Free article.
The role of particulate matter-associated zinc in cardiac injury in rats.
Kodavanti UP, Schladweiler MC, Gilmour PS, Wallenborn JG, Mandavilli BS, Ledbetter AD, Christiani DC, Runge MS, Karoly ED, Costa DL, Peddada S, Jaskot R, Richards JH, Thomas R, Madamanchi NR, Nyska A. Kodavanti UP, et al. Among authors: gilmour ps. Environ Health Perspect. 2008 Jan;116(1):13-20. doi: 10.1289/ehp.10379. Environ Health Perspect. 2008. PMID: 18197293 Free PMC article.
40 results