Gopalsamy A - Search Results

1

Identification of pyrimidine derivatives as hSMG-1 inhibitors.

Gopalsamy A, Bennett EM, Shi M, Zhang WG, Bard J, Yu K. Gopalsamy A, et al. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6636-41. doi: 10.1016/j.bmcl.2012.08.107. Epub 2012 Sep 7. Bioorg Med Chem Lett. 2012. PMID: 23021994

2

Novel synthetic approach to 6,7-dihydro-5H-imidazo[1,5-a]-pyrazin-8-ones.

Gopalsamy A, Shi M. Gopalsamy A, et al. Org Lett. 2003 Oct 16;5(21):3907-9. doi: 10.1021/ol035455i. Org Lett. 2003. PMID: 14535740

3

Design and synthesis of oxadiazolidinediones as inhibitors of plasminogen activator inhibitor-1.

Gopalsamy A, Kincaid SL, Ellingboe JW, Groeling TM, Antrilli TM, Krishnamurthy G, Aulabaugh A, Friedrichs GS, Crandall DL. Gopalsamy A, et al. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3477-80. doi: 10.1016/j.bmcl.2004.04.058. Bioorg Med Chem Lett. 2004. PMID: 15177456

4

Identification of [(naphthalene-1-carbonyl)-amino]-acetic acid derivatives as nonnucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase.

Gopalsamy A, Lim K, Ellingboe JW, Krishnamurthy G, Orlowski M, Feld B, van Zeijl M, Howe AY. Gopalsamy A, et al. Bioorg Med Chem Lett. 2004 Aug 16;14(16):4221-4. doi: 10.1016/j.bmcl.2004.06.013. Bioorg Med Chem Lett. 2004. PMID: 15261274

5

Pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as novel anti-proliferative agents: parallel synthesis for lead optimization of amide region.

Gopalsamy A, Yang H, Ellingboe JW, Tsou HR, Zhang N, Honores E, Powell D, Miranda M, McGinnis JP, Rabindran SK. Gopalsamy A, et al. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1591-4. doi: 10.1016/j.bmcl.2005.01.066. Bioorg Med Chem Lett. 2005. PMID: 15745803

6

Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships.

Gavrin LK, Green N, Hu Y, Janz K, Kaila N, Li HQ, Tam SY, Thomason JR, Gopalsamy A, Ciszewski G, Cuozzo JW, Hall JP, Hsu S, Telliez JB, Lin LL. Gavrin LK, et al. Among authors: gopalsamy a. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5288-92. doi: 10.1016/j.bmcl.2005.08.029. Epub 2005 Sep 13. Bioorg Med Chem Lett. 2005. PMID: 16165349

7

Design and synthesis of 3,4-dihydro-1H-[1]-benzothieno[2,3-c]pyran and 3,4-dihydro-1H-pyrano[3,4-b]benzofuran derivatives as non-nucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase.

Gopalsamy A, Aplasca A, Ciszewski G, Park K, Ellingboe JW, Orlowski M, Feld B, Howe AY. Gopalsamy A, et al. Bioorg Med Chem Lett. 2006 Jan 15;16(2):457-60. doi: 10.1016/j.bmcl.2005.08.114. Epub 2005 Nov 7. Bioorg Med Chem Lett. 2006. PMID: 16274990

8

Design and synthesis of 2,3,4,9-tetrahydro-1H-carbazole and 1,2,3,4-tetrahydro-cyclopenta[b]indole derivatives as non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase.

Gopalsamy A, Shi M, Ciszewski G, Park K, Ellingboe JW, Orlowski M, Feld B, Howe AY. Gopalsamy A, et al. Bioorg Med Chem Lett. 2006 May 1;16(9):2532-4. doi: 10.1016/j.bmcl.2006.01.105. Epub 2006 Feb 15. Bioorg Med Chem Lett. 2006. PMID: 16480869

9

Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding site.

Gopalsamy A, Chopra R, Lim K, Ciszewski G, Shi M, Curran KJ, Sukits SF, Svenson K, Bard J, Ellingboe JW, Agarwal A, Krishnamurthy G, Howe AY, Orlowski M, Feld B, O'Connell J, Mansour TS. Gopalsamy A, et al. J Med Chem. 2006 Jun 1;49(11):3052-5. doi: 10.1021/jm060168g. J Med Chem. 2006. PMID: 16722622

10

Discovery of dibenzo[c,f][2,7]naphthyridines as potent and selective 3-phosphoinositide-dependent kinase-1 inhibitors.

Gopalsamy A, Shi M, Boschelli DH, Williamson R, Olland A, Hu Y, Krishnamurthy G, Han X, Arndt K, Guo B. Gopalsamy A, et al. J Med Chem. 2007 Nov 15;50(23):5547-9. doi: 10.1021/jm070851i. Epub 2007 Oct 17. J Med Chem. 2007. PMID: 17941624

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