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Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue.
Imaizumi Y, Okada Y, Akamatsu W, Koike M, Kuzumaki N, Hayakawa H, Nihira T, Kobayashi T, Ohyama M, Sato S, Takanashi M, Funayama M, Hirayama A, Soga T, Hishiki T, Suematsu M, Yagi T, Ito D, Kosakai A, Hayashi K, Shouji M, Nakanishi A, Suzuki N, Mizuno Y, Mizushima N, Amagai M, Uchiyama Y, Mochizuki H, Hattori N, Okano H. Imaizumi Y, et al. Among authors: uchiyama y. Mol Brain. 2012 Oct 6;5:35. doi: 10.1186/1756-6606-5-35. Mol Brain. 2012. PMID: 23039195 Free PMC article.
Possible involvement of iron-induced oxidative insults in neurodegeneration.
Asano T, Koike M, Sakata S, Takeda Y, Nakagawa T, Hatano T, Ohashi S, Funayama M, Yoshimi K, Asanuma M, Toyokuni S, Mochizuki H, Uchiyama Y, Hattori N, Iwai K. Asano T, et al. Among authors: uchiyama y. Neurosci Lett. 2015 Feb 19;588:29-35. doi: 10.1016/j.neulet.2014.12.052. Epub 2014 Dec 27. Neurosci Lett. 2015. PMID: 25549542 Free article.
Long-term safety issues of iPSC-based cell therapy in a spinal cord injury model: oncogenic transformation with epithelial-mesenchymal transition.
Nori S, Okada Y, Nishimura S, Sasaki T, Itakura G, Kobayashi Y, Renault-Mihara F, Shimizu A, Koya I, Yoshida R, Kudoh J, Koike M, Uchiyama Y, Ikeda E, Toyama Y, Nakamura M, Okano H. Nori S, et al. Among authors: uchiyama y. Stem Cell Reports. 2015 Mar 10;4(3):360-73. doi: 10.1016/j.stemcr.2015.01.006. Epub 2015 Feb 13. Stem Cell Reports. 2015. PMID: 25684226 Free PMC article.
Variants in saposin D domain of prosaposin gene linked to Parkinson's disease.
Oji Y, Hatano T, Ueno SI, Funayama M, Ishikawa KI, Okuzumi A, Noda S, Sato S, Satake W, Toda T, Li Y, Hino-Takai T, Kakuta S, Tsunemi T, Yoshino H, Nishioka K, Hattori T, Mizutani Y, Mutoh T, Yokochi F, Ichinose Y, Koh K, Shindo K, Takiyama Y, Hamaguchi T, Yamada M, Farrer MJ, Uchiyama Y, Akamatsu W, Wu YR, Matsuda J, Hattori N. Oji Y, et al. Among authors: uchiyama y. Brain. 2020 Apr 1;143(4):1190-1205. doi: 10.1093/brain/awaa064. Brain. 2020. PMID: 32201884
Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor functional recovery after spinal cord injury in mice.
Nori S, Okada Y, Yasuda A, Tsuji O, Takahashi Y, Kobayashi Y, Fujiyoshi K, Koike M, Uchiyama Y, Ikeda E, Toyama Y, Yamanaka S, Nakamura M, Okano H. Nori S, et al. Among authors: uchiyama y. Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16825-30. doi: 10.1073/pnas.1108077108. Epub 2011 Sep 26. Proc Natl Acad Sci U S A. 2011. PMID: 21949375 Free PMC article.
Homeostatic p62 levels and inclusion body formation in CHCHD2 knockout mice.
Sato S, Noda S, Torii S, Amo T, Ikeda A, Funayama M, Yamaguchi J, Fukuda T, Kondo H, Tada N, Arakawa S, Watanabe M, Uchiyama Y, Shimizu S, Hattori N. Sato S, et al. Among authors: uchiyama y. Hum Mol Genet. 2021 Apr 30;30(6):443-453. doi: 10.1093/hmg/ddab057. Hum Mol Genet. 2021. PMID: 33631794
1,221 results