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Page 1
Oxidative stress-regulated lentiviral TK/GCV gene therapy for lung cancer treatment.
Leinonen HM, Ruotsalainen AK, Määttä AM, Laitinen HM, Kuosmanen SM, Kansanen E, Pikkarainen JT, Lappalainen JP, Samaranayake H, Lesch HP, Kaikkonen MU, Ylä-Herttuala S, Levonen AL. Leinonen HM, et al. Among authors: lappalainen jp. Cancer Res. 2012 Dec 1;72(23):6227-35. doi: 10.1158/0008-5472.CAN-12-1166. Epub 2012 Oct 4. Cancer Res. 2012. PMID: 23041549
The absence of macrophage Nrf2 promotes early atherogenesis.
Ruotsalainen AK, Inkala M, Partanen ME, Lappalainen JP, Kansanen E, Mäkinen PI, Heinonen SE, Laitinen HM, Heikkilä J, Vatanen T, Hörkkö S, Yamamoto M, Ylä-Herttuala S, Jauhiainen M, Levonen AL. Ruotsalainen AK, et al. Among authors: lappalainen jp. Cardiovasc Res. 2013 Apr 1;98(1):107-15. doi: 10.1093/cvr/cvt008. Epub 2013 Jan 22. Cardiovasc Res. 2013. PMID: 23341579
Nuclear factor E2-related factor 2 deficiency impairs atherosclerotic lesion development but promotes features of plaque instability in hypercholesterolaemic mice.
Ruotsalainen AK, Lappalainen JP, Heiskanen E, Merentie M, Sihvola V, Näpänkangas J, Lottonen-Raikaslehto L, Kansanen E, Adinolfi S, Kaarniranta K, Ylä-Herttuala S, Jauhiainen M, Pirinen E, Levonen AL. Ruotsalainen AK, et al. Among authors: lappalainen jp. Cardiovasc Res. 2019 Jan 1;115(1):243-254. doi: 10.1093/cvr/cvy143. Cardiovasc Res. 2019. PMID: 29917052
Differential regulation of angiogenic cellular processes and claudin-5 by histamine and VEGF via PI3K-signaling, transcription factor SNAI2 and interleukin-8.
Laakkonen JP, Lappalainen JP, Theelen TL, Toivanen PI, Nieminen T, Jauhiainen S, Kaikkonen MU, Sluimer JC, Ylä-Herttuala S. Laakkonen JP, et al. Among authors: lappalainen jp. Angiogenesis. 2017 Feb;20(1):109-124. doi: 10.1007/s10456-016-9532-7. Epub 2016 Nov 21. Angiogenesis. 2017. PMID: 27873103
BMP6/TAZ-Hippo signaling modulates angiogenesis and endothelial cell response to VEGF.
Pulkkinen HH, Kiema M, Lappalainen JP, Toropainen A, Beter M, Tirronen A, Holappa L, Niskanen H, Kaikkonen MU, Ylä-Herttuala S, Laakkonen JP. Pulkkinen HH, et al. Among authors: lappalainen jp. Angiogenesis. 2021 Feb;24(1):129-144. doi: 10.1007/s10456-020-09748-4. Epub 2020 Oct 6. Angiogenesis. 2021. PMID: 33021694 Free PMC article.
In vivo phage display screening for tumor vascular targets in glioblastoma identifies a llama nanobody against dynactin-1-p150Glued.
van Lith SA, Roodink I, Verhoeff JJ, Mäkinen PI, Lappalainen JP, Ylä-Herttuala S, Raats J, van Wijk E, Roepman R, Letteboer SJ, Verrijp K, Leenders WP. van Lith SA, et al. Among authors: lappalainen jp. Oncotarget. 2016 Nov 1;7(44):71594-71607. doi: 10.18632/oncotarget.12261. Oncotarget. 2016. PMID: 27689404 Free PMC article.
Macrophage selective photodynamic therapy by meta-tetra(hydroxyphenyl)chlorin loaded polymeric micelles: A possible treatment for cardiovascular diseases.
Wennink JWH, Liu Y, Mäkinen PI, Setaro F, de la Escosura A, Bourajjaj M, Lappalainen JP, Holappa LP, van den Dikkenberg JB, Al Fartousi M, Trohopoulos PN, Ylä-Herttuala S, Torres T, Hennink WE, van Nostrum CF. Wennink JWH, et al. Among authors: lappalainen jp. Eur J Pharm Sci. 2017 Sep 30;107:112-125. doi: 10.1016/j.ejps.2017.06.038. Epub 2017 Jul 2. Eur J Pharm Sci. 2017. PMID: 28679107 Free article.
Angiopoietin-2 blocking antibodies reduce early atherosclerotic plaque development in mice.
Theelen TL, Lappalainen JP, Sluimer JC, Gurzeler E, Cleutjens JP, Gijbels MJ, Biessen EA, Daemen MJ, Alitalo K, Ylä-Herttuala S. Theelen TL, et al. Among authors: lappalainen jp. Atherosclerosis. 2015 Aug;241(2):297-304. doi: 10.1016/j.atherosclerosis.2015.05.018. Epub 2015 Jun 3. Atherosclerosis. 2015. PMID: 26062989 Free PMC article.