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Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system.
Kirkby NS, Lundberg MH, Harrington LS, Leadbeater PD, Milne GL, Potter CM, Al-Yamani M, Adeyemi O, Warner TD, Mitchell JA. Kirkby NS, et al. Among authors: milne gl. Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17597-602. doi: 10.1073/pnas.1209192109. Epub 2012 Oct 8. Proc Natl Acad Sci U S A. 2012. PMID: 23045674 Free PMC article.
Inherited human group IVA cytosolic phospholipase A2 deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation.
Kirkby NS, Reed DM, Edin ML, Rauzi F, Mataragka S, Vojnovic I, Bishop-Bailey D, Milne GL, Longhurst H, Zeldin DC, Mitchell JA, Warner TD. Kirkby NS, et al. Among authors: milne gl. FASEB J. 2015 Nov;29(11):4568-78. doi: 10.1096/fj.15-275065. Epub 2015 Jul 16. FASEB J. 2015. PMID: 26183771 Free PMC article. Clinical Trial.
Identification of a homozygous recessive variant in PTGS1 resulting in a congenital aspirin-like defect in platelet function.
Chan MV, Hayman MA, Sivapalaratnam S, Crescente M, Allan HE, Edin ML, Zeldin DC, Milne GL, Stephens J, Greene D, Hanif M, O'Donnell VB, Dong L, Malkowski MG, Lentaigne C, Wedderburn K, Stubbs M, Downes K, Ouwehand WH, Turro E, BioResource N, Hart DP, Freson K, Laffan MA, Warner TD. Chan MV, et al. Among authors: milne gl. Haematologica. 2021 May 1;106(5):1423-1432. doi: 10.3324/haematol.2019.235895. Haematologica. 2021. PMID: 32299908 Free PMC article.
Synthesis of a Human Urinary Metabolite of Prostaglandin D2.
Kimbrough JR, Austin Z, Milne GL, Sulikowski GA. Kimbrough JR, et al. Among authors: milne gl. Org Lett. 2019 Dec 20;21(24):10048-10051. doi: 10.1021/acs.orglett.9b03983. Epub 2019 Dec 4. Org Lett. 2019. PMID: 31799855
Azithromycin Causes a Novel Proarrhythmic Syndrome.
Yang Z, Prinsen JK, Bersell KR, Shen W, Yermalitskaya L, Sidorova T, Luis PB, Hall L, Zhang W, Du L, Milne G, Tucker P, George AL Jr, Campbell CM, Pickett RA, Shaffer CM, Chopra N, Yang T, Knollmann BC, Roden DM, Murray KT. Yang Z, et al. Circ Arrhythm Electrophysiol. 2017 Apr;10(4):e003560. doi: 10.1161/CIRCEP.115.003560. Circ Arrhythm Electrophysiol. 2017. PMID: 28408648 Free PMC article.
236 results