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Switching a Xanthine Oxidase Inhibitor to a Dual-Target Antagonist of P2Y1 and P2Y12 as an Oral Antiplatelet Agent with a Wider Therapeutic Window in Rats than Ticagrelor.
Lei Y, Zhang B, Liu D, Zhao J, Dai X, Gao J, Mao Q, Feng Y, Zhao J, Lin F, Duan Y, Zhang Y, Bao Z, Yang Y, Mou Y, Wang S. Lei Y, et al. Among authors: zhao j. J Med Chem. 2020 Dec 24;63(24):15752-15772. doi: 10.1021/acs.jmedchem.0c01524. Epub 2020 Dec 12. J Med Chem. 2020. PMID: 33307675
Discovery of 4-(3-aminopyrrolidinyl)-3-aryl-5-(benzimidazol-2-yl)-pyridines as potent and selective SST5 agonists for the treatment of congenital hyperinsulinism.
Zhao J, Wang S, Hee Kim S, Han S, Rico-Bautista E, Sturchler E, Nguyen J, Tan H, Staley C, Karin Kusnetzow A, Betz SF, Johns M, Goulet L, Luo R, Fowler M, Athanacio J, Markison S, Scott Struthers R, Zhu Y. Zhao J, et al. Bioorg Med Chem Lett. 2022 Sep 1;71:128807. doi: 10.1016/j.bmcl.2022.128807. Epub 2022 May 20. Bioorg Med Chem Lett. 2022. PMID: 35605837
Discovery of CRN04894: A Novel Potent Selective MC2R Antagonist.
Kim SH, Han S, Zhao J, Wang S, Kusnetzow AK, Reinhart G, Fowler MA, Markison S, Johns M, Luo R, Struthers RS, Zhu Y, Betz SF. Kim SH, et al. Among authors: zhao j. ACS Med Chem Lett. 2024 Mar 19;15(4):478-485. doi: 10.1021/acsmedchemlett.3c00514. eCollection 2024 Apr 11. ACS Med Chem Lett. 2024. PMID: 38628803
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