Sousa M - Search Results

1

Measurements of CFTR-mediated Cl- secretion in human rectal biopsies constitute a robust biomarker for Cystic Fibrosis diagnosis and prognosis.

Sousa M, Servidoni MF, Vinagre AM, Ramalho AS, Bonadia LC, Felício V, Ribeiro MA, Uliyakina I, Marson FA, Kmit A, Cardoso SR, Ribeiro JD, Bertuzzo CS, Sousa L, Kunzelmann K, Ribeiro AF, Amaral MD. Sousa M, et al. Among authors: sousa l. PLoS One. 2012;7(10):e47708. doi: 10.1371/journal.pone.0047708. Epub 2012 Oct 17. PLoS One. 2012. PMID: 23082198 Free PMC article.

2

Comparative ex vivo, in vitro and in silico analyses of a CFTR splicing mutation: Importance of functional studies to establish disease liability of mutations.

Ramalho AS, Clarke LA, Sousa M, Felicio V, Barreto C, Lopes C, Amaral MD. Ramalho AS, et al. Among authors: sousa m. J Cyst Fibros. 2016 Jan;15(1):21-33. doi: 10.1016/j.jcf.2015.02.002. Epub 2015 Feb 27. J Cyst Fibros. 2016. PMID: 25735457 Free article.

3

Folding and rescue of a cystic fibrosis transmembrane conductance regulator trafficking mutant identified using human-murine chimeric proteins.

Da Paula AC, Sousa M, Xu Z, Dawson ES, Boyd AC, Sheppard DN, Amaral MD. Da Paula AC, et al. Among authors: sousa m. J Biol Chem. 2010 Aug 27;285(35):27033-27044. doi: 10.1074/jbc.M110.120352. Epub 2010 Jun 15. J Biol Chem. 2010. PMID: 20551307 Free PMC article.

4

Contribution of casein kinase 2 and spleen tyrosine kinase to CFTR trafficking and protein kinase A-induced activity.

Luz S, Kongsuphol P, Mendes AI, Romeiras F, Sousa M, Schreiber R, Matos P, Jordan P, Mehta A, Amaral MD, Kunzelmann K, Farinha CM. Luz S, et al. Among authors: sousa m. Mol Cell Biol. 2011 Nov;31(22):4392-404. doi: 10.1128/MCB.05517-11. Epub 2011 Sep 19. Mol Cell Biol. 2011. PMID: 21930781 Free PMC article.

5

HGF stimulation of Rac1 signaling enhances pharmacological correction of the most prevalent cystic fibrosis mutant F508del-CFTR.

Moniz S, Sousa M, Moraes BJ, Mendes AI, Palma M, Barreto C, Fragata JI, Amaral MD, Matos P. Moniz S, et al. Among authors: sousa m. ACS Chem Biol. 2013 Feb 15;8(2):432-42. doi: 10.1021/cb300484r. Epub 2012 Nov 20. ACS Chem Biol. 2013. PMID: 23148778

6

Rectal forceps biopsy procedure in cystic fibrosis: technical aspects and patients perspective for clinical trials feasibility.

Servidoni MF, Sousa M, Vinagre AM, Cardoso SR, Ribeiro MA, Meirelles LR, de Carvalho RB, Kunzelmann K, Ribeiro AF, Ribeiro JD, Amaral MD. Servidoni MF, et al. Among authors: sousa m. BMC Gastroenterol. 2013 May 20;13:91. doi: 10.1186/1471-230X-13-91. BMC Gastroenterol. 2013. PMID: 23688510 Free PMC article.

7

High-content siRNA screen reveals global ENaC regulators and potential cystic fibrosis therapy targets.

Almaça J, Faria D, Sousa M, Uliyakina I, Conrad C, Sirianant L, Clarke LA, Martins JP, Santos M, Heriché JK, Huber W, Schreiber R, Pepperkok R, Kunzelmann K, Amaral MD. Almaça J, et al. Among authors: sousa m. Cell. 2013 Sep 12;154(6):1390-400. doi: 10.1016/j.cell.2013.08.045. Cell. 2013. PMID: 24034256 Free article.

8

Increased efficacy of VX-809 in different cellular systems results from an early stabilization effect of F508del-CFTR.

Farinha CM, Sousa M, Canato S, Schmidt A, Uliyakina I, Amaral MD. Farinha CM, et al. Among authors: sousa m. Pharmacol Res Perspect. 2015 Aug;3(4):e00152. doi: 10.1002/prp2.152. Epub 2015 Jun 11. Pharmacol Res Perspect. 2015. PMID: 26171232 Free PMC article.

9

Revertants, low temperature, and correctors reveal the mechanism of F508del-CFTR rescue by VX-809 and suggest multiple agents for full correction.

Farinha CM, King-Underwood J, Sousa M, Correia AR, Henriques BJ, Roxo-Rosa M, Da Paula AC, Williams J, Hirst S, Gomes CM, Amaral MD. Farinha CM, et al. Among authors: sousa m. Chem Biol. 2013 Jul 25;20(7):943-55. doi: 10.1016/j.chembiol.2013.06.004. Chem Biol. 2013. PMID: 23890012

10

An extract from the medicinal plant Phyllanthus acidus and its isolated compounds induce airway chloride secretion: A potential treatment for cystic fibrosis.

Sousa M, Ousingsawat J, Seitz R, Puntheeranurak S, Regalado A, Schmidt A, Grego T, Jansakul C, Amaral MD, Schreiber R, Kunzelmann K. Sousa M, et al. Mol Pharmacol. 2007 Jan;71(1):366-76. doi: 10.1124/mol.106.025262. Epub 2006 Oct 25. Mol Pharmacol. 2007. PMID: 17065237

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