Wright GE - Search Results

1

Modified diadenosine tetraphosphates with dual specificity for P2Y1 and P2Y12 are potent antagonists of ADP-induced platelet activation.

Chang H, Yanachkov IB, Dix EJ, Li YF, Barnard MR, Wright GE, Michelson AD, Frelinger AL 3rd. Chang H, et al. Among authors: wright ge. J Thromb Haemost. 2012 Dec;10(12):2573-80. doi: 10.1111/jth.12035. J Thromb Haemost. 2012. PMID: 23083103 Free PMC article.

2

Antiplatelet activity, P2Y₁ and P2Y₁₂ inhibition, and metabolism in plasma of stereoisomers of diadenosine 5',5'″-P¹ ,P⁴-dithio-P²,P³-chloromethylenetetraphosphate.

Chang H, Yanachkov IB, Dix EJ, Yanachkova M, Li Y, Barnard MR, Wright GE, Michelson AD, Frelinger AL 3rd. Chang H, et al. Among authors: wright ge. PLoS One. 2014 Apr 10;9(4):e94780. doi: 10.1371/journal.pone.0094780. eCollection 2014. PLoS One. 2014. PMID: 24722456 Free PMC article.

3

New highly active antiplatelet agents with dual specificity for platelet P2Y1 and P2Y12 adenosine diphosphate receptors.

Yanachkov IB, Chang H, Yanachkova MI, Dix EJ, Berny-Lang MA, Gremmel T, Michelson AD, Wright GE, Frelinger AL 3rd. Yanachkov IB, et al. Among authors: wright ge. Eur J Med Chem. 2016 Jan 1;107:204-18. doi: 10.1016/j.ejmech.2015.10.055. Epub 2015 Nov 9. Eur J Med Chem. 2016. PMID: 26588064 Free PMC article.

4

Synergistic Inhibition of Both P2Y1 and P2Y12 Adenosine Diphosphate Receptors As Novel Approach to Rapidly Attenuate Platelet-Mediated Thrombosis.

Gremmel T, Yanachkov IB, Yanachkova MI, Wright GE, Wider J, Undyala VV, Michelson AD, Frelinger AL 3rd, Przyklenk K. Gremmel T, et al. Among authors: wright ge. Arterioscler Thromb Vasc Biol. 2016 Mar;36(3):501-9. doi: 10.1161/ATVBAHA.115.306885. Epub 2016 Jan 7. Arterioscler Thromb Vasc Biol. 2016. PMID: 26743169 Free PMC article.

5

GLS-409, an Antagonist of Both P2Y₁ and P2Y₁₂, Potently Inhibits Canine Coronary Artery Thrombosis and Reversibly Inhibits Human Platelet Activation.

Smolensky Koganov E, Michelson AD, Yanachkov IB, Yanachkova MI, Wright GE, Przyklenk K, Frelinger AL 3rd. Smolensky Koganov E, et al. Among authors: wright ge. Sci Rep. 2018 Sep 28;8(1):14529. doi: 10.1038/s41598-018-32797-1. Sci Rep. 2018. PMID: 30266987 Free PMC article.

6

Agonist and antagonist effects of diadenosine tetraphosphate, a platelet dense granule constituent, on platelet P2Y1, P2Y12 and P2X1 receptors.

Chang H, Yanachkov IB, Michelson AD, Li Y, Barnard MR, Wright GE, Frelinger AL 3rd. Chang H, et al. Among authors: wright ge. Thromb Res. 2010 Feb;125(2):159-65. doi: 10.1016/j.thromres.2009.11.006. Epub 2009 Nov 27. Thromb Res. 2010. PMID: 19945153 Free PMC article.

7

P1,P2-diimidazolyl derivatives of pyrophosphate and bis-phosphonates--synthesis, properties, and use in preparation of dinucleoside tetraphosphates and analogs.

Yanachkov IB, Dix EJ, Yanachkova MI, Wright GE. Yanachkov IB, et al. Among authors: wright ge. Org Biomol Chem. 2011 Feb 7;9(3):730-8. doi: 10.1039/c0ob00542h. Epub 2010 Nov 17. Org Biomol Chem. 2011. PMID: 21082127 Free PMC article.

8

Publisher Correction: GLS-409, an Antagonist of Both P2Y₁ and P2Y₁₂, Potently Inhibits Canine Coronary Artery Thrombosis and Reversibly Inhibits Human Platelet Activation.

Smolensky Koganov E, Michelson AD, Yanachkov IB, Yanachkova MI, Wright GE, Przyklenk K, Frelinger AL 3rd. Smolensky Koganov E, et al. Among authors: wright ge. Sci Rep. 2018 Nov 29;8(1):17580. doi: 10.1038/s41598-018-35956-6. Sci Rep. 2018. PMID: 30498241 Free PMC article.

9

A novel agent effective against Clostridium difficile infection.

Dvoskin S, Xu WC, Brown NC, Yanachkov IB, Yanachkova M, Wright GE. Dvoskin S, et al. Among authors: wright ge. Antimicrob Agents Chemother. 2012 Mar;56(3):1624-6. doi: 10.1128/AAC.06097-11. Epub 2011 Dec 27. Antimicrob Agents Chemother. 2012. PMID: 22203600 Free PMC article.

10

Synthesis and effect of nonhydrolyzable xanthosine triphosphate derivatives on prenylation of Rab5D136N.

Yanachkov I, Pan JY, Wessling-Resnick M, Wright GE. Yanachkov I, et al. Among authors: wright ge. Mol Pharmacol. 1997 Jan;51(1):47-51. doi: 10.1124/mol.51.1.47. Mol Pharmacol. 1997. PMID: 9016345

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