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Increased uracil insertion in DNA is cytotoxic and increases the frequency of mutation, double strand break formation and VSG switching in Trypanosoma brucei.
Castillo-Acosta VM, Aguilar-Pereyra F, Bart JM, Navarro M, Ruiz-Pérez LM, Vidal AE, González-Pacanowska D. Castillo-Acosta VM, et al. Among authors: vidal ae. DNA Repair (Amst). 2012 Dec 1;11(12):986-95. doi: 10.1016/j.dnarep.2012.09.007. Epub 2012 Oct 22. DNA Repair (Amst). 2012. PMID: 23085192
Base excision repair plays an important role in the protection against nitric oxide- and in vivo-induced DNA damage in Trypanosoma brucei.
Yagüe-Capilla M, García-Caballero D, Aguilar-Pereyra F, Castillo-Acosta VM, Ruiz-Pérez LM, Vidal AE, González-Pacanowska D. Yagüe-Capilla M, et al. Among authors: vidal ae. Free Radic Biol Med. 2019 Feb 1;131:59-71. doi: 10.1016/j.freeradbiomed.2018.11.025. Epub 2018 Nov 22. Free Radic Biol Med. 2019. PMID: 30472364
29 results