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Akt phosphorylates the transcriptional repressor bmi1 to block its effects on the tumor-suppressing ink4a-arf locus.
Liu Y, Liu F, Yu H, Zhao X, Sashida G, Deblasio A, Harr M, She QB, Chen Z, Lin HK, Di Giandomenico S, Elf SE, Yang Y, Miyata Y, Huang G, Menendez S, Mellinghoff IK, Rosen N, Pandolfi PP, Hedvat CV, Nimer SD. Liu Y, et al. Among authors: chen z. Sci Signal. 2012 Oct 23;5(247):ra77. doi: 10.1126/scisignal.2003199. Sci Signal. 2012. PMID: 23092893 Free PMC article.
NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN.
Wang X, Trotman LC, Koppie T, Alimonti A, Chen Z, Gao Z, Wang J, Erdjument-Bromage H, Tempst P, Cordon-Cardo C, Pandolfi PP, Jiang X. Wang X, et al. Among authors: chen z. Cell. 2007 Jan 12;128(1):129-39. doi: 10.1016/j.cell.2006.11.039. Cell. 2007. PMID: 17218260 Free PMC article.
Ubiquitination regulates PTEN nuclear import and tumor suppression.
Trotman LC, Wang X, Alimonti A, Chen Z, Teruya-Feldstein J, Yang H, Pavletich NP, Carver BS, Cordon-Cardo C, Erdjument-Bromage H, Tempst P, Chi SG, Kim HJ, Misteli T, Jiang X, Pandolfi PP. Trotman LC, et al. Among authors: chen z. Cell. 2007 Jan 12;128(1):141-56. doi: 10.1016/j.cell.2006.11.040. Cell. 2007. PMID: 17218261 Free PMC article.
Differential requirement of mTOR in postmitotic tissues and tumorigenesis.
Nardella C, Carracedo A, Alimonti A, Hobbs RM, Clohessy JG, Chen Z, Egia A, Fornari A, Fiorentino M, Loda M, Kozma SC, Thomas G, Cordon-Cardo C, Pandolfi PP. Nardella C, et al. Among authors: chen z. Sci Signal. 2009 Jan 27;2(55):ra2. doi: 10.1126/scisignal.2000189. Sci Signal. 2009. PMID: 19176516 Free PMC article.
ETS rearrangements and prostate cancer initiation.
Carver BS, Tran J, Chen Z, Carracedo-Perez A, Alimonti A, Nardella C, Gopalan A, Scardino PT, Cordon-Cardo C, Gerald W, Pandolfi PP. Carver BS, et al. Among authors: chen z. Nature. 2009 Feb 12;457(7231):E1; discussion E2-3. doi: 10.1038/nature07738. Nature. 2009. PMID: 19212347 Free PMC article.
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