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Down-regulation of Shadoo in prion infections traces a pre-clinical event inversely related to PrP(Sc) accumulation.
Westaway D, Genovesi S, Daude N, Brown R, Lau A, Lee I, Mays CE, Coomaraswamy J, Canine B, Pitstick R, Herbst A, Yang J, Ko KW, Schmitt-Ulms G, Dearmond SJ, McKenzie D, Hood L, Carlson GA. Westaway D, et al. Among authors: lau a. PLoS Pathog. 2011 Nov;7(11):e1002391. doi: 10.1371/journal.ppat.1002391. Epub 2011 Nov 17. PLoS Pathog. 2011. PMID: 22114562 Free PMC article.
Interactome analyses identify ties of PrP and its mammalian paralogs to oligomannosidic N-glycans and endoplasmic reticulum-derived chaperones.
Watts JC, Huo H, Bai Y, Ehsani S, Jeon AH, Shi T, Daude N, Lau A, Young R, Xu L, Carlson GA, Williams D, Westaway D, Schmitt-Ulms G. Watts JC, et al. Among authors: lau a. PLoS Pathog. 2009 Oct;5(10):e1000608. doi: 10.1371/journal.ppat.1000608. Epub 2009 Oct 2. PLoS Pathog. 2009. PMID: 19798432 Free PMC article.
Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation.
Lau A, McDonald A, Daude N, Mays CE, Walter ED, Aglietti R, Mercer RC, Wohlgemuth S, van der Merwe J, Yang J, Gapeshina H, Kim C, Grams J, Shi B, Wille H, Balachandran A, Schmitt-Ulms G, Safar JG, Millhauser GL, Westaway D. Lau A, et al. EMBO Mol Med. 2015 Mar;7(3):339-56. doi: 10.15252/emmm.201404588. EMBO Mol Med. 2015. PMID: 25661904 Free PMC article.
Prion disease tempo determined by host-dependent substrate reduction.
Mays CE, Kim C, Haldiman T, van der Merwe J, Lau A, Yang J, Grams J, Di Bari MA, Nonno R, Telling GC, Kong Q, Langeveld J, McKenzie D, Westaway D, Safar JG. Mays CE, et al. Among authors: lau a. J Clin Invest. 2014 Feb;124(2):847-58. doi: 10.1172/JCI72241. Epub 2014 Jan 16. J Clin Invest. 2014. PMID: 24430187 Free PMC article.
2,238 results