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9-substituted 6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazoles as highly selective and potent anaplastic lymphoma kinase inhibitors.
Kinoshita K, Kobayashi T, Asoh K, Furuichi N, Ito T, Kawada H, Hara S, Ohwada J, Hattori K, Miyagi T, Hong WS, Park MJ, Takanashi K, Tsukaguchi T, Sakamoto H, Tsukuda T, Oikawa N. Kinoshita K, et al. Among authors: sakamoto h. J Med Chem. 2011 Sep 22;54(18):6286-94. doi: 10.1021/jm200652u. Epub 2011 Aug 25. J Med Chem. 2011. PMID: 21823617
Discovery of 6-benzyloxyquinolines as c-Met selective kinase inhibitors.
Nishii H, Chiba T, Morikami K, Fukami TA, Sakamoto H, Ko K, Koyano H. Nishii H, et al. Among authors: sakamoto h. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1405-9. doi: 10.1016/j.bmcl.2009.12.109. Epub 2010 Jan 4. Bioorg Med Chem Lett. 2010. PMID: 20093027
Discovery of novel tetracyclic compounds as anaplastic lymphoma kinase inhibitors.
Kinoshita K, Ono Y, Emura T, Asoh K, Furuichi N, Ito T, Kawada H, Tanaka S, Morikami K, Tsukaguchi T, Sakamoto H, Tsukuda T, Oikawa N. Kinoshita K, et al. Among authors: sakamoto h. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3788-93. doi: 10.1016/j.bmcl.2011.04.020. Epub 2011 Apr 22. Bioorg Med Chem Lett. 2011. PMID: 21561771
Enhanced inhibition of ERK signaling by a novel allosteric MEK inhibitor, CH5126766, that suppresses feedback reactivation of RAF activity.
Ishii N, Harada N, Joseph EW, Ohara K, Miura T, Sakamoto H, Matsuda Y, Tomii Y, Tachibana-Kondo Y, Iikura H, Aoki T, Shimma N, Arisawa M, Sowa Y, Poulikakos PI, Rosen N, Aoki Y, Sakai T. Ishii N, et al. Among authors: sakamoto h. Cancer Res. 2013 Jul 1;73(13):4050-4060. doi: 10.1158/0008-5472.CAN-12-3937. Epub 2013 May 10. Cancer Res. 2013. PMID: 23667175 Free PMC article.
CH7233163 Overcomes Osimertinib-Resistant EGFR-Del19/T790M/C797S Mutation.
Kashima K, Kawauchi H, Tanimura H, Tachibana Y, Chiba T, Torizawa T, Sakamoto H. Kashima K, et al. Among authors: sakamoto h. Mol Cancer Ther. 2020 Nov;19(11):2288-2297. doi: 10.1158/1535-7163.MCT-20-0229. Epub 2020 Sep 17. Mol Cancer Ther. 2020. PMID: 32943545
Enantioselective synthesis of derivatives and structure-activity relationship study in the development of NA255 as a novel host-targeting anti-HCV agent.
Kawasaki K, Masubuchi M, Hayase T, Komiyama S, Watanabe F, Fukuda H, Murata T, Matsubara Y, Koyama K, Shindoh H, Sakamoto H, Okamato K, Ohta A, Katsume A, Aoki M, Aoki Y, Shimma N, Sudoh M, Tsukuda T. Kawasaki K, et al. Among authors: sakamoto h. Bioorg Med Chem Lett. 2013 Jan 1;23(1):336-9. doi: 10.1016/j.bmcl.2012.10.083. Epub 2012 Oct 30. Bioorg Med Chem Lett. 2013. PMID: 23164713
3,084 results